The safest drug to use to treat pregnant women with deep vein thrombosis is:
- A. Low-molecular-weight heparin
- B. Warfarin
- C. Aspirin
- D. Heparin
Correct Answer: D
Rationale: Heparin is safest in pregnancy as it doesn't cross the placenta, unlike warfarin (B, teratogenic); LMWH is also safe but not listed as 'heparin.'
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Which statement is not correct about metformin:
- A. Is for internal use only
- B. Reduce weight, apetite
- C. More frequently causes nausea and vomiting comparing with other hypoglicemic drugs
- D. Use for diabetes mellitus type I
Correct Answer: D
Rationale: Metformin is not typically used for type 1 diabetes, which requires insulin, as it acts on insulin sensitivity and hepatic glucose production.
A nurse is preparing to administer medications to a 4-month-old infant. Which of the following pharmacokinetic principles should the nurse consider when administering medications to this client?
- A. Infants have a more rapid gastric emptying time.
- B. Infants have normal liver function.
- C. Infants have a more rapid gastric emptying time.
- D. Infants have an increased ability to absorb topical medications.
Correct Answer: D
Rationale: Immature liver function affects metabolism, and increased topical absorption occurs due to thinner skin; rapid gastric emptying (A,C) is incorrect.
The FDA established a safety information and adverse events reporting program called MedWatch. Which individuals can access the MedWatch website to obtain safety alerts on drugs, devices, or dietary supplements?
- A. Physicians
- B. Nurses
- C. Patients
- D. All of the above
Correct Answer: D
Rationale: Anyone can access the MedWatch website to obtain safety alerts on drugs, devices, or dietary supplements.
A doctor orders 250 mL of IV fluid to be infused over 1 hour using microdrip tubing (60 gtt/mL). What is the flow rate in drops per minute?
- A. 100 gtt/min
- B. 120 gtt/min
- C. 150 gtt/min
- D. 250 gtt/min
Correct Answer: D
Rationale: Flow rate = (250 mL 60 gtt/mL) ÷ (1 60) = 15,000 ÷ 60 = 250 gtt/min, matching microdrip where mL/hr = gtt/min.
A classic drug interaction resulting in an increased bleeding time, involves warfarin and:
- A. Vitamin B6
- B. Aspirin
- C. Folic acid
- D. Rifampin
Correct Answer: B
Rationale: Aspirin inhibits platelet aggregation, enhancing warfarin's anticoagulant effect and increasing bleeding risk.