Nokea
This graph illustrates the dose-response relationship for the effect of the beta agonist isoproterenol on an isolated perfused heart, both alone and in the presence of different fixed concentrations of Drug X. Based upon the data shown, Drug X is most likely a(n):
- A. beta agonist
- B. competitive antagonist
- C. irreversible antagonist
- D. noncompetitive antagonist
Correct Answer: A
Rationale: Without the graph, the answer key indicates Drug X is a beta agonist, suggesting it enhances or mimics isoproterenol's effect, likely shifting the curve upward or leftward.
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A client has an order to receive 10 units of intermediate-acting insulin at bedtime via subcutaneous injection. The nurse would expect to administer the injection at which site? Select one that does not apply.
- A. Upper arm
- B. Inner forearm
- C. Upper abdomen
- D. Upper thigh
Correct Answer: B
Rationale: The sites for subcutaneous injection are the upper arms, the upper abdomen, and the upper thighs.
Alpha-beta blockers are especially effective to treat hypertension for which ethnic group?
- A. White
- B. Asian
- C. African American
- D. Native American
Correct Answer: C
Rationale: Alpha-beta blockers are particularly effective in African Americans due to their dual mechanism.
In response to the patient's question about how to know whether drugs are safe, the nurse explains that all medications undergo rigorous scientific testing controlled by what organization?
- A. Food and Drug Administration (FDA)
- B. Drug Enforcement Agency (DEA)
- C. Centers for Disease Control and Prevention (CDC)
- D. Joint Commission on Accreditation of Healthcare Organizations (JCAHO)
Correct Answer: A
Rationale: The FDA is responsible for controlling and regulating the development and sale of drugs in the United States, allowing new drugs to enter the market only after being subjected to rigorous scientific testing. The DEA regulates and controls the use of controlled substances. The CDC monitors and responds to infectious diseases. The JCAHO is an accrediting body that inspects acute care facilities to ensure minimum standards are met.
Which statement best describes drug efficacy/toxicity in pediatric patients?
- A. Drug requirements for infants have been extensively studied.
- B. Drug dosage is altered by age and weight in children.
- C. Children always need smaller doses of medication than adults.
- D. Infants and children are not at risk for drug toxicity if the dosage is correct
Correct Answer: B
Rationale: Pediatric dosing adjusts for age and weight due to varying metabolism and body composition.
A nurse working for a drug company is involved in phase III drug evaluation studies. Which of the following might the nurse be responsible for during this stage of drug development?
- A. Working with animals who are given experimental drugs
- B. Monitoring drug effects in patients who are selected to participate in a study, who have the disease that the drug is meant to treat
- C. Collecting records of symptoms that participants experience while taking a drug and determining whether they are caused by the disease or the drug
- D. Informing healthy, young volunteer participants of possible risks that could occur from taking an experimental drug
Correct Answer: C
Rationale: Phase III studies involve use of a drug in a vast clinical market where patients are asked to record any symptoms they experience while taking the drugs. Nurses may be responsible for helping collect and analyze the information to be shared with the Food and Drug Administration (FDA). Use of animals in drug testing is done in the preclinical trials. A select group of patients who are involved in phase II studies participate in studies where the participants have the disease the drug is intended to treat. These patients are monitored closely for drug effects. Phase I studies involve healthy human volunteers who are usually paid for their participation. Nurses may observe for adverse effects and toxicity.