Nokea
This is the basis for calculation of infant dose in Clark's Rule :
- A. age ;
- B. weight ;
- C. height ;
- D. surface area ;
Correct Answer: B
Rationale: In Clark's Rule, the basis for calculating the infant dose is weight. This is because weight is a crucial factor in determining the appropriate dosage for infants. Adjusting the dose based on weight helps in ensuring that the medication is administered safely and effectively. Infants have different proportions of body weight compared to older children and adults, which can influence how medications are metabolized in their bodies. Therefore, using weight as the basis for dosage calculation in Clark's Rule helps in providing a more accurate and individualized dose for infants.
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Which of the following drugs has a therapeutic effect that increases cardiac output and slows heart rate?
- A. Heparin
- B. Alprazola
- C. Digoxin
- D. Levothyroxine
Correct Answer: C
Rationale: Digoxin is a medication commonly used to treat heart failure and certain types of irregular heartbeats. It works by increasing the force of contraction of the heart muscle, thereby increasing cardiac output. Additionally, digoxin also has the ability to slow down the heart rate, making it helpful in conditions such as atrial fibrillation. Heparin is an anticoagulant medication used to prevent blood clot formation, while Alprazolam is a benzodiazepine used to treat anxiety disorders. Levothyroxine is a thyroid hormone replacement medication to treat hypothyroidism. None of these drugs have the therapeutic effects of increasing cardiac output and slowing heart rate like digoxin.
A patient is experiencing mucositis (stomatitis) after receiving chemotherapy. Which symptomatic treatments will be appropriate? (Select all that apply.)
- A. Frequent mouth rinses
- B. Antiemetics
- C. Topical anesthetics
- D. Stress reduction
Correct Answer: A
Rationale: Mucositis, or stomatitis, is a painful inflammation of the mucous membranes caused by chemotherapy. Frequent mouth rinses with saline or baking soda solutions help keep the mouth clean and promote healing. Topical anesthetics, such as lidocaine, can provide pain relief. Stress reduction techniques, such as relaxation or mindfulness, may help manage the discomfort associated with mucositis. Antiemetics are used to control nausea and vomiting, which are not directly related to mucositis. Antibiotics are only necessary if there is a secondary infection, which is not mentioned in this scenario.
An injection of penicillin into a penicillin-sensitized person may lead to death due to:
- A. absence of histamine
- B. a Shwartzman's reaction
- C. release of enzymes from polymorphonuclear leukocytes
- D. constriction of bronchioli and drop in blood pressure
Correct Answer: B
Rationale: A Shwartzman's reaction is a severe inflammatory response that occurs when a person who has previously been sensitized to penicillin is re-exposed to the drug. This exaggerated response can lead to widespread activation of inflammatory mediators and is characterized by endotoxin-induced intravascular coagulation. This can result in a cascade of events leading to tissue damage, organ failure, and potentially death. It is different from a typical allergic reaction mediated by histamine release or constriction of bronchioli and drop in blood pressure. Additionally, the release of enzymes from polymorphonuclear leukocytes is not directly related to the fatal outcome of a penicillin injection in a sensitized individual.
Which of the following medications would you administer for an overdose of acetaminophen?
- A. Naloxone
- B. Vitamin K
- C. Acetylcysteine
- D. Atropine
Correct Answer: C
Rationale: Acetylcysteine is the specific antidote for acetaminophen overdose. Acetaminophen (also known as paracetamol) toxicity can cause severe liver damage if not treated promptly. Acetylcysteine works by replenishing the depleted glutathione stores in the liver, helping to prevent liver damage and improving the patient's outcome. Naloxone is used for opioid overdose, vitamin K for reversing the effects of certain anticoagulants, and atropine for specific heart and nerve related conditions.
A patient who has been anticoagulated with warfarin (Coumadin) has been admitted for gastrointestinal bleeding. The history and physical examination indicates that the patient may have taken too much warfarin. The nurse anticipates that the patient will receive which antidote?
- A. Vitamin E
- B. Vitamin K
- C. Protamine sulfate
- D. Potassium chloride
Correct Answer: B
Rationale: Vitamin K is the antidote for warfarin (Coumadin) toxicity. Warfarin is a vitamin K antagonist that inhibits the synthesis of vitamin K-dependent coagulation factors (II, VII, IX, X) in the liver. In cases of excessive anticoagulation and bleeding, administering vitamin K can help reverse the effects of warfarin by replenishing the depleted vitamin K-dependent clotting factors. Vitamin K helps the liver produce clotting factors, thereby promoting the clotting process and reversing the excessive anticoagulant effects of warfarin. Other options mentioned, such as Vitamin E, Protamine sulfate, and Potassium chloride, are not appropriate antidotes for warfarin toxicity.