Nokea
Ultra-rapid metabolizers of drugs may have:
- A. To have dosages of drugs adjusted downward to prevent drug accumulation
- B. Active drug rapidly metabolized into inactive metabolites, leading to potential therapeutic failure
- C. Increased elimination of active, nonmetabolized drug
- D. Slowed metabolism of a prodrug into an active drug, leading to an accumulation of prodrug
Correct Answer: B
Rationale: Ultra-rapid metabolizers (e.g., CYP2D6) quickly inactivate drugs , risking therapeutic failure, requiring higher doses, not lower or slowed metabolism .
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Teaching the patient/caregiver about their medications is an important step in reducing the risk of medication errors. What is an important teaching point about medications?
- A. Speak up
- B. Store medications in a warm humid place
- C. Adjust your medication according to your weight
- D. Keep a list of your prescribed medications
Correct Answer: D
Rationale: Keeping a medication list enhances safety by ensuring all providers know current drugs, reducing error risk.
Tamoxifen is prescribed for the client with metastatic breast carcinoma. The nurse understands that the primary action of this medication is to:
- A. Increase DNA and RNA synthesis.
- B. Promote the biosynthesis of nucleic acids.
- C. Increase estrogen concentration and estrogen response.
- D. Compete with estradiol for binding to estrogen in tissues containing high concentrations of receptors.
Correct Answer: D
Rationale: Tamoxifen is an antineoplastic medication that competes with estradiol for binding to estrogen in tissues containing high concentrations of receptors. Tamoxifen is used to treat metastatic breast carcinoma in women and men. Tamoxifen is also effective in delaying the recurrence of cancer following mastectomy. Tamoxifen reduces DNA synthesis and estrogen response.
A nurse is teaching a client who has a new prescription for Brimonidine ophthalmic drops and wears soft contact lenses. Which of the following instructions should the nurse include in the teaching?
- A. This medication can stain your contacts.
- B. This medication can cause your pupils to constrict.
- C. This medication can absorb into your contacts.
- D. This medication can slow your heart rate.
Correct Answer: C
Rationale: Brimonidine can absorb into contacts , requiring removal before use to avoid irritation.
The primary action of loop diuretics is to:
- A. Inhibit sodium and chloride reabsorption in the loop of Henle.
- B. Block aldosterone receptors in the distal tubule.
- C. Increase osmolarity of the renal tubular fluid.
- D. Inhibit sodium reabsorption in the proximal tubule.
Correct Answer: A
Rationale: Loop diuretics like furosemide inhibit Na+/Cl- reabsorption in the loop of Henle, increasing urine output.
A patient asks the nurse, What is a Drug Enforcement Agency (DEA) number? What is the nurses best response?
- A. DEA Numbers are given to physicians and pharmacists when they register with the DEA to prescribe and dispense controlled substances.
- B. Physicians must have a DEA number in order to prescribe any type of medication for patients.
- C. DEA numbers are case numbers given when someone breaks the law involving a controlled substance.
- D. DEA numbers are contact numbers to talk with someone at the DEA when questions arise about controlled substances.
Correct Answer: A
Rationale: All pharmacists and physicians must register with the DEA. They are given numbers that are required before they can dispense or prescribe controlled substances. DEA numbers are only needed when prescribing controlled substances. A DEA number is neither a case number nor a phone number.