Nokea
When involved in phase III drug evaluation studies, what responsibilities would the nurse have?
- A. Working with animals who are given experimental drugs
- B. Choosing appropriate patients to be involved in the drug study
- C. Monitoring and observing patients closely for adverse effects
- D. Conducting research to determine effectiveness of the drug
Correct Answer: C
Rationale: In phase III studies, nurses monitor patients closely for adverse effects (C) in a large clinical population, collecting data for FDA review, per the text. Animal work (A) occurs in preclinical phases, patient selection (B) is for phase II, and independent research (D) isn't a nurse's role as they don't prescribe, making C the primary responsibility.
You may also like to solve these questions
Which of the following choices is the process by which a substance is transported against a concentration gradient?
- A. Passive transfer
- B. Active transport
- C. Facilitated diffusion
- D. Filtration
Correct Answer: B
Rationale: Active transport (B) uses energy to move against gradients, per the text, making it correct. A and D are passive, C uses carriers but not against gradients, confirming B.
A patient has been using sleeping pills every night for the past several months. Now admitted to the hospital, he is prescribed his usual dose of sleeping pill. After administration, the patient continues to be restless and is wide awake. The nurse notifies the health care provider, who prescribes an increased dose. After receiving the new dose, the patient falls asleep. The nurse interprets this as which of the following?
- A. Drug idiosyncrasy
- B. Cumulative drug effect
- C. Drug tolerance
- D. Toxic reactions
Correct Answer: C
Rationale: Drug tolerance (C) explains needing a higher dose for effect after prolonged use, per the text. Idiosyncrasy (A) is unusual, cumulative effect (B) is buildup, and toxicity (D) is overdose. The text defines tolerance as reduced response, matching this scenario.
After teaching a group of nursing students about pharmacokinetics, the instructor determines that the teaching was successful when the students identify which of the following as the site for the metabolism of most drugs?
- A. Liver
- B. Lungs
- C. Kidneys
- D. Intestinal mucosa
Correct Answer: A
Rationale: The liver (A) is the primary metabolism site for most drugs, per the text. Lungs (B), kidneys (C), and mucosa (D) play lesser roles. Students' correct choice aligns with the text's emphasis on hepatic metabolism, confirming effective teaching.
Which medication route provides the most rapid onset of a medication but also poses the greatest risk of adverse effects?
- A. Intradermal
- B. Subcutaneous (subcut)
- C. Intramuscular (IM)
- D. Intravenous (IV)
Correct Answer: D
Rationale: D' is correct because intravenous (IV) administration delivers drugs directly into the bloodstream, bypassing absorption barriers for the fastest onset, but its immediacy increases adverse effect risks, per pharmacokinetics. 'A' (intradermal) is slow, for testing. 'B' (subcut) and 'C' (IM) have slower absorption via tissues. IV's directness requires careful monitoring, balancing speed with safety concerns.
The nurse explains the Drug Enforcement Agency (DEA's) schedule of controlled substances to the nursing assistant who asks, 'Do you ever get a prescription for Schedule I medications?' What is the nurse's best response?
- A. Schedule I medications have no medical use so they are not prescribed
- B. Schedule I medications have the lowest risk for abuse and do not require a prescription
- C. Schedule I medications are only prescribed in monitored units for patient safety
- D. Schedule I medications are found in antitussives and antidiarrheals sold over the counter
Correct Answer: A
Rationale: Schedule I drugs (A) have no medical use and aren't prescribed, per the text, making it the best response. Low risk (B) is Schedule V, monitored units (C) isn't standard, and OTC (D) is Schedule V, so A is correct.