Nokea
When taken with aminoglycosides, platinum chemotherapy or cyclosporin increase the risk of
- A. Kidney damage
- B. Ototoxicity
Correct Answer: A
Rationale: Platinum chemotherapy (e.g., cisplatin) and cyclosporin both potentiate aminoglycoside nephrotoxicity, increasing kidney damage risk.
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The rotavirus vaccine (RotaTeq, Rotarix):
- A. Is a live vaccine that replicates in the small intestine, providing active immunity against rotavirus
- B. Should not be given to infants who are or may be potentially immunocompromised
- C. Is not given to an infant who has a febrile illness (temperature greater than 100.5°F)
- D. All of the above
Correct Answer: D
Rationale: All are true: rotavirus vaccine is live , contraindicated in immunocompromise , and deferred with fever .
A nurse is preparing a teaching plan for a client who is prescribed an oral medication. As part of the plan, the nurse expects to describe the importance of absorption. The nurse would integrate knowledge of which of the following as a mechanism for absorption in the gastrointestinal tract? Select one that does not apply.
- A. Active transport
- B. Transposition
- C. Passive transport
- D. Pinocytosis
Correct Answer: B
Rationale: During absorption, the drug particles in the GI tract are moved into the body fluids via active transport, passive transport, and pinocytosis.
A client with Crohn's disease is scheduled to receive an infusion of infliximab (Remicade). The nurse assisting in caring for the client should take which action to monitor the effectiveness of treatment?
- A. Monitoring the leukocyte count for 2 days after the infusion
- B. Checking the frequency and consistency of bowel movements
- C. Checking serum liver enzyme levels before and after the infusion
- D. Carrying out a Hematest on gastric fluids after the infusion is completed
Correct Answer: B
Rationale: The principal manifestations of Crohn's disease are diarrhea and abdominal pain. Infliximab (Remicade) is an immunomodulator that reduces the degree of inflammation in the colon, thereby reducing the diarrhea. Options 1, 3, and 4 are unrelated to this medication.
A patient is being seen in the clinic for rheumatoid arthritis. Which of the following statements would indicate that she may be developing a complication from her rheumatoid medication, chloroquine (Aralen)?
- A. I have to urinate all the time.'
- B. Sometimes I have blurred vision.'
- C. I have tingling and numbness in my arms and legs.'
- D. Sometimes I feel like I am losing my balance when I walk.'
Correct Answer: B
Rationale: Chloroquine (Aralen) can cause ocular toxicity with blurring of vision, color vision changes, corneal damage, and blindness. Increased urination and tingling and numbness are signs of hyperkalemia and hypokalemia. Loss of balance can be caused by auditory damage due to drug toxicity.
The nurse is reviewing the results of the patient's laboratory tests. What must the nurse keep in mind when reviewing these results related to medication administration?
- A. The patient's emotional response to the disease process
- B. The timing of the last dose of medication relative to when blood was drawn
- C. The possibility of a drug-laboratory test interaction
- D. A change in the body's responses or actions related to the drug
Correct Answer: C
Rationale: The body works through a series of chemical reactions. Because of this, administration of a particular drug may alter results of tests that are done on various chemical levels or reactions as part of a diagnostic study. This drug-laboratory test interaction is caused by the drug being given and not necessarily by a change in the body's responses or actions. The patient's emotional response or timing of the last dose is not important in drug-laboratory interactions.