Nokea
Which bacteria are known to produce an endotoxin that can cause septic shock?
- A. Salmonella enterica
- B. Escherichia coli
- C. Pseudomonas aeruginosa
- D. All of the above
Correct Answer: D
Rationale: The correct answer is D because all three bacteria (Salmonella enterica, Escherichia coli, Pseudomonas aeruginosa) are known to produce endotoxins, specifically lipopolysaccharides in their cell walls. Endotoxins are released upon bacterial cell death and can trigger an immune response, leading to septic shock. Salmonella and E. coli are common causes of bacterial infections, while Pseudomonas is associated with nosocomial infections. Therefore, all of the above choices are correct in terms of producing endotoxins that can cause septic shock. Choices A, B, and C are incorrect individually because they do not encompass all the bacteria known to produce endotoxins that can lead to septic shock.
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A child with fever and a sore throat had a Gram-stained smear revealing Gram-positive cocci in chains. The bacteria were beta-hemolytic. What is the likely causative agent?
- A. Streptococcus pyogenes
- B. Streptococcus pneumoniae
- C. Staphylococcus aureus
- D. Enterococcus faecalis
Correct Answer: A
Rationale: The correct answer is A: Streptococcus pyogenes. The presence of Gram-positive cocci in chains suggests a streptococcal infection. Beta-hemolysis indicates the production of a hemolysin that lyses red blood cells, a characteristic of Streptococcus pyogenes. This bacterium is known to cause strep throat and can present with fever and sore throat.
Summary:
- B: Streptococcus pneumoniae is a common cause of pneumonia but typically appears as lancet-shaped cocci, not in chains.
- C: Staphylococcus aureus is a gram-positive cocci in clusters, not chains, and is not typically beta-hemolytic.
- D: Enterococcus faecalis is a gram-positive cocci that are part of the normal gut flora and are not typically beta-hemolytic or found in chains.
In which of the following cases of immune reactions a large lattice is formed?
- A. Antibody is in excess
- B. Antigens and antibodies are in optimal proportion
- C. Antigen is in excess
- D. None of the above
Correct Answer: B
Rationale: The correct answer is B because in immune reactions, a large lattice is formed when antigens and antibodies are in optimal proportion. This optimal ratio allows for the formation of a strong antigen-antibody complex, leading to the aggregation of immune complexes into large lattice structures. When antibodies are in excess (choice A), there may not be enough antigens to form a stable lattice. Similarly, when antigens are in excess (choice C), there may be insufficient antibodies to form a strong lattice. Choice D is incorrect because the optimal proportion of antigens and antibodies is crucial for the formation of large lattices in immune reactions.
Endotoxins are released upon:
- A. bacterial replication
- B. cell lysis of gram-negative bacteria
- C. antibody production
- D. formation of spores
Correct Answer: B
Rationale: The correct answer is B because endotoxins are part of the outer membrane of gram-negative bacteria. When these bacteria undergo cell lysis, the endotoxins are released, causing harmful effects. This process does not occur during bacterial replication (choice A), antibody production (choice C), or formation of spores (choice D). Bacterial replication involves the creation of new bacterial cells, not the release of endotoxins. Antibody production is the immune response to pathogens, not the direct cause of endotoxin release. Spores are dormant structures formed by some bacteria, which are not directly related to the release of endotoxins.
Agglutination reaction is one of the following:
- A. Western blot
- B. ELISA
- C. Reaction type GRUBER
- D. Ascoli ring test
Correct Answer: C
Rationale: The correct answer is C: Reaction type GRUBER. Agglutination reaction in GRUBER involves the clumping of particles due to specific antibodies binding to antigens on the surface. This reaction is commonly used in blood typing and serology tests.
A: Western blot is a technique used to detect specific proteins in a sample, not related to agglutination.
B: ELISA is an enzyme-linked immunosorbent assay used to detect antibodies or antigens, not based on agglutination.
D: Ascoli ring test is a method to detect the presence of DNA in a sample, not related to agglutination.
Detection of galactomannan and free mannan is used for diagnosing:
- A. Aspergillosis and candidiasis
- B. HIV infection
- C. Syphilis
- D. Leptospirosis
Correct Answer: A
Rationale: The correct answer is A: Aspergillosis and candidiasis. Galactomannan is a polysaccharide found in Aspergillus cell walls and is detected in patients with invasive aspergillosis. Free mannan is a polysaccharide found in Candida cell walls and is detected in patients with candidiasis. Therefore, detection of galactomannan and free mannan is specific for diagnosing Aspergillosis and candidiasis. Choices B, C, and D are incorrect as HIV infection, syphilis, and leptospirosis do not involve the detection of galactomannan or free mannan for diagnosis.