Nokea
Which drug undergoes extensive first-pass hepatic metabolism?
- A. Heparin
- B. Insulin
- C. Propranolol
- D. Nitroglycerin
Correct Answer: C
Rationale: Propranolol undergoes extensive first-pass metabolism in the liver. When administered orally, propranolol is extensively metabolized by the liver before reaching systemic circulation, leading to reduced bioavailability. This process is known as first-pass hepatic metabolism, which significantly affects the drug's effectiveness and necessitates higher oral doses compared to other routes of administration.
You may also like to solve these questions
What is the expected pharmacological action of propranolol?
- A. Block stimulation of beta1 receptors
- B. Alter water and electrolyte transport in the large intestine
- C. Block stimulation of beta2 receptors
- D. Both A and C are correct
Correct Answer: D
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
A client is receiving vancomycin. Which of the following laboratory results should be monitored to evaluate the therapeutic effect of this medication?
- A. BUN
- B. Creatinine
- C. Hemoglobin
- D. White blood cell count
Correct Answer: B
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
A client is receiving Enoxaparin for the prevention of deep vein thrombosis. Which of the following actions should the nurse take?
- A. Massage the injection site after administration.
- B. Administer the medication intramuscularly.
- C. Administer the medication into the subcutaneous tissue.
- D. Administer the medication into the deltoid muscle.
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
A client is receiving Cefotaxime IV for a severe infection. Which finding indicates a potentially serious adverse reaction to this medication that the nurse should report to the provider?
- A. Diaphoresis
- B. Epistaxis
- C. Diarrhea
- D. Alopecia
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
The toddler refuses to take his oral medication. What is the best suggestion to the mother from the nurse for ensuring the toddler receives his medication?
- A. Tell him you will buy him a toy if he takes the medication
- B. Crush the tablet and mix it with a small amount of jam
- C. Crush the tablet and mix it with milk
- D. Tell him he will be punished if he does not take the medicine
Correct Answer: B
Rationale: Toddlers (1-3) resist meds-crushing a tablet (if safe) and mixing with jam masks taste, easing intake, per developmental needs. Bribery with toys may not work long-term. Milk risks interactions (e.g., tetracycline) or dilution. Punishment distresses, not helps. Jam leverages taste preference, ensuring delivery.