Nokea
Which of the antibiotics listed below are not suitable for treatment of listeriosis?
- A. Penicillin and ampicillin
- B. Macrolids
- C. Cephalosporins
- D. None of them
Correct Answer: B
Rationale: The correct answer is B: Macrolides. Listeriosis is typically treated with antibiotics such as Penicillin and ampicillin due to their effectiveness against Listeria monocytogenes. Macrolides, on the other hand, are not first-line agents for listeriosis treatment. They are less effective in treating this bacterial infection compared to Penicillin and ampicillin. Cephalosporins may also be less effective against Listeria monocytogenes compared to Penicillin and ampicillin. Choice D is incorrect as Macrolides are not suitable for listeriosis treatment.
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After a prolonged isoniazid treatment, the patient developed polyneuritis, paresthesia, memory disorders, and convulsions. What is the most likely mechanism of the described isoniazid side-effects?
- A. Disruption of cell membrane synthesis
- B. Inhibition of protein synthesis
- C. Inhibition of RNA-synthesis
- D. Inhibition of pyridoxal phosphate synthesis
Correct Answer: D
Rationale: The correct answer is D. Isoniazid inhibits pyridoxal phosphate synthesis, which is the active form of vitamin B6. Pyridoxal phosphate is essential for various enzymatic reactions, including neurotransmitter synthesis and myelin formation. Therefore, isoniazid-induced pyridoxal phosphate deficiency can lead to neurological symptoms like polyneuritis, paresthesia, memory disorders, and convulsions.
A: Disruption of cell membrane synthesis - This is not the mechanism of isoniazid side-effects.
B: Inhibition of protein synthesis - Isoniazid does not directly inhibit protein synthesis.
C: Inhibition of RNA-synthesis - Isoniazid does not inhibit RNA synthesis; it affects vitamin B6 metabolism.
When examining a patient with a suspicion of food toxicoinfection, a doctor on duty has detected symptoms characteristic of botulism. The patient named the meals he had eaten the day before. What is the most probable cause of infection?
- A. Homemade canned meat
- B. Custard pastry from private bakery
- C. Sour cream from local dairy factory
- D. Strawberries from suburban vegetable garden
Correct Answer: A
Rationale: The correct answer is A: Homemade canned meat. Botulism is often caused by consuming improperly canned or preserved foods, particularly meats. The spores of the Clostridium botulinum bacteria can grow in anaerobic conditions, such as those found in improperly canned foods, leading to the production of the botulinum toxin. The symptoms of botulism align with those characteristic of the patient's condition.
Explanation of why the other choices are incorrect:
B: Custard pastry from private bakery - Unlikely to be the cause of botulism as this type of food is not typically associated with the growth of Clostridium botulinum.
C: Sour cream from local dairy factory - While dairy products can sometimes be sources of foodborne illness, botulism is not commonly associated with sour cream.
D: Strawberries from suburban vegetable garden - Botulism is not typically transmitted through fresh fruits or vegetables, making this an unlikely source of infection.
Which of the following bacteria is known for causing the disease known as whooping cough?
- A. Bordetella pertussis
- B. Clostridium tetani
- C. Haemophilus influenzae
- D. Staphylococcus aureus
Correct Answer: A
Rationale: The correct answer is A: Bordetella pertussis. This bacterium is known for causing whooping cough due to its ability to produce toxins that damage the respiratory tract, leading to severe coughing fits. Clostridium tetani causes tetanus, Haemophilus influenzae can cause respiratory infections but not whooping cough, and Staphylococcus aureus is more commonly associated with skin infections. Therefore, A is the correct choice based on its specific association with the disease in question.
A pregnant woman applied to a doctor with complaints typical for toxoplasmosis. The doctor took a sample of her blood. What serological tests should be performed in this case?
- A. Complement binding assay
- B. Precipitation test
- C. Neutralization test
- D. Widal's test
Correct Answer: A
Rationale: The correct serological test for diagnosing toxoplasmosis is the Complement Binding Assay (A) because it detects antibodies specific to the Toxoplasma gondii parasite. This test is highly sensitive and specific for toxoplasmosis.
Choice B, Precipitation test, is not used for toxoplasmosis diagnosis but rather for other diseases like syphilis.
Choice C, Neutralization test, is not specific for toxoplasmosis and is used for other types of infections.
Choice D, Widal's test, is used for diagnosing typhoid fever and is not relevant for toxoplasmosis.
In summary, the correct answer (A) is specific to toxoplasmosis, while the other choices are used for different diseases and are not suitable for diagnosing toxoplasmosis.
Which bacteria is known for causing a disease characterized by a pseudomembrane in the throat?
- A. Clostridium tetani
- B. Bordetella pertussis
- C. Corynebacterium diphtheriae
- D. Streptococcus pyogenes
Correct Answer: C
Rationale: The correct answer is C: Corynebacterium diphtheriae. This bacterium causes diphtheria, a disease characterized by a pseudomembrane in the throat. This pseudomembrane is a result of the bacterial exotoxins causing inflammation and necrosis of the throat tissues. Clostridium tetani (A) causes tetanus, characterized by muscle stiffness, not a pseudomembrane in the throat. Bordetella pertussis (B) causes whooping cough, with symptoms of severe coughing fits but no pseudomembrane. Streptococcus pyogenes (D) causes strep throat, but does not produce a pseudomembrane.