Which of the following changes would be expected to occur with increased binding of a hormone to plasma proteins?
Correct Answer: D
Rationale: Step 1: Increased binding of a hormone to plasma proteins reduces the concentration of free hormone in the blood.
Step 2: With decreased free hormone levels, there is less hormone available to exert its effects.
Step 3: This reduction in free hormone would lead to an increase in the degree of negative feedback exerted by the hormone to regulate its own production.
Therefore, the correct answer is D.
Summary:
A: Increase in plasma clearance of the hormone - Incorrect. Increased binding to plasma proteins would decrease clearance.
B: Decrease in half-life of the hormone - Incorrect. Increased binding can prolong the half-life by protecting the hormone from degradation.
C: Increase in hormone activity - Incorrect. Increased binding reduces the availability of free hormone, decreasing its activity.