HESI Medical Surgical Practice Exam Related

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Which of the following conditions is the most significant risk factor for the development of type 2 diabetes mellitus?

  • A. Cigarette smoking.
  • B. High-cholesterol diet.
  • C. Obesity.
  • D. Hypertension.
Correct Answer: C

Rationale: Obesity is the most significant risk factor for developing type 2 diabetes mellitus due to its role in insulin resistance. Excess body fat, especially around the abdomen, leads to increased production of inflammatory markers and hormones that can cause insulin resistance. While cigarette smoking, high-cholesterol diet, and hypertension can contribute to health issues, they are not as directly linked to the development of type 2 diabetes mellitus as obesity.