2019 ATI Pharmacology Proctored Exam Related

Review 2019 ATI Pharmacology Proctored Exam related questions and content

Which of the following diuretics inhibits sodium reabsorption in the kidneys while saving K+ and Hydrogen ions?

  • A. Spironolactone
  • B. Furosemide
  • C. Hydrochlorothiazide
  • D. Bumetanide
Correct Answer: A

Rationale: Spironolactone is a potassium-sparing diuretic, which means it inhibits sodium reabsorption in the kidneys, while saving potassium and hydrogen ions. It accomplishes this by acting as an aldosterone antagonist, blocking the action of aldosterone. Aldosterone is a hormone that normally promotes sodium reabsorption in the kidneys and leads to potassium and hydrogen ion excretion. By inhibiting aldosterone, spironolactone promotes sodium excretion while conserving potassium and hydrogen ions.