Nokea
Which of the following drugs interacts with nitroglycerine by inhibiting the metabolism of cGMP?
- A. Amyl nitrite
- B. Sildenafil
- C. Isosorbide mononitrate
- D. Nifedipine
Correct Answer: B
Rationale: Sildenafil, a PDE5 inhibitor, increases cGMP, enhancing nitroglycerin's hypotensive effect.
You may also like to solve these questions
A patient comes to the ER having his quadriceps muscle constantly contracted, you should give him:
- A. Norepinephrine to stimulate the sympathetic nervous system
- B. An antagonist for Norepinephrine
- C. Agonist for acetylcholine
- D. Both B and C
Correct Answer: D
Rationale: Both B and C are correct: a norepinephrine antagonist (e.g., beta-blocker) or acetylcholine agonist (e.g., to relax via parasympathetic action) could relieve muscle contraction.
The choice of diuretic to use in treating hypertension is based on:
- A. Presence of diabetes with loop diuretics being used for these patients
- B. Level of kidney function with a thiazide diuretic being used for an estimated glomerular filtration rate higher than the mid-40 mL/min range
- C. Ethnicity with aldosterone antagonists best for African Americans and older adults
- D. Presence of hyperlipidemia with higher doses needed for patients with LDL above 130 mg/dL
Correct Answer: B
Rationale: Thiazides are effective with GFR >40-50 mL/min; loops are used for lower GFR.
When patients are started on darbepoetin alfa (Aranesp) they need monitoring of their blood counts to determine a dosage adjustment in:
- A. 6 weeks if they are a cancer patient
- B. 1 week if they have chronic renal failure
- C. 2 weeks if they are taking it for allogenic transfusion
- D. Each week throughout therapy
Correct Answer: A
Rationale: Cancer patients need blood count checks at 6 weeks for darbepoetin adjustment; renal patients adjust sooner, typically 2-4 weeks.
L-Dopa is
- A. Converted to methyl dopa in the body
- B. Antagonised by riboflavine
- C. Antagonized by nicotinic acid
- D. Combined with carbidopa for enhanced effect
Correct Answer: D
Rationale: Carbidopa enhances L-Dopa's effect by preventing peripheral breakdown.
A nurse in a provider's office is instructing a parent of a toddler how to administer ear drops. Which of the following instructions should the nurse include? (Select one that does not apply.)
- A. Place the child on his unaffected side when you are ready to administer the medication.
- B. Warm the medication by gently rolling it between your hands for a few minutes.
- C. Gently shake medication that is in suspension form.
- D. Keep the child on his side for 5 minutes after institution of the ear drops.
Correct Answer: C
Rationale: Side position , warming , and keeping on side ensure proper administration and absorption.