Nokea
Which of the following fungicidal drug that acts by inhibiting fungal squalene * epoxidase enzyme and is the drug of choice for onymycosis of the toe nails in 56 year old woman with diabetes?
- A. Griseofulvin
- B. Terbinane
- C. Itraconazole
- D. Amphotiricin B
Correct Answer: B
Rationale: Rationale: Terbinafine is the correct answer as it inhibits fungal squalene epoxidase, disrupting ergosterol synthesis in the fungal cell membrane. This drug is specifically effective against onychomycosis in diabetic patients due to its fungicidal action and good nail penetration. Griseofulvin (A) targets microtubules, not squalene epoxidase. Itraconazole (C) inhibits ergosterol synthesis via a different mechanism. Amphotericin B (D) disrupts fungal cell membrane by binding to ergosterol, not squalene epoxidase.
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Which of the following would be examples of foods selected to lower the pH of urine?
- A. Milk
- B. Tea
- C. Apples
- D. Meat
Correct Answer: C
Rationale: The correct answer is C: Apples. Apples are acidic in nature, which can help lower the pH of urine. Consuming acidic foods can make the urine more acidic. Milk is alkaline, so it would raise the pH of urine. Tea can vary in acidity, but generally it is not chosen to lower urine pH. Meat is also not acidic and would not contribute to lowering urine pH. So, apples are the most suitable choice for lowering urine pH among the options provided.
Spironolactone can be usefully combined with the following diuretics except: *
- A. Amiloride
- B. Chlorthalidone
- C. Furosemide
- D. Hydrochlorothiazide
Correct Answer: D
Rationale: Spironolactone is a potassium-sparing diuretic, so combining it with another potassium-sparing diuretic like amiloride can lead to hyperkalemia. Chlorthalidone, a thiazide-like diuretic, can be synergistic with spironolactone. Furosemide, a loop diuretic, can counteract the potassium-sparing effects of spironolactone. Hydrochlorothiazide, a thiazide diuretic, can also lead to hypokalemia when combined with spironolactone. Therefore, the correct answer is D, as combining spironolactone with hydrochlorothiazide may increase the risk of potassium imbalance.
The female gonad is called a(n)
- A. placenta
- B. fallopian tube
- C. fimbria
- D. ovary
Correct Answer: D
Rationale: The correct answer is D: ovary. The female gonad is the primary reproductive organ that produces eggs and secretes hormones. The ovary is specifically responsible for these functions. Placenta (A) is an organ formed during pregnancy, fallopian tube (B) is a part of the female reproductive system that transports eggs, and fimbria (C) are finger-like projections at the end of the fallopian tube. Therefore, the ovary is the only choice that accurately represents the female gonad.
A 45-year-old mother of two children is seen at the clinic for complaints of “losing my urine when I sneeze.†The nurse documents that she is experiencing:
- A. Urinary frequency.
- B. Enuresis.
- C. Stress incontinence.
- D. Urge incontinence.
Correct Answer: C
Rationale: The correct answer is C: Stress incontinence. This type of incontinence is characterized by leakage of urine during activities that increase intra-abdominal pressure, such as sneezing, coughing, or laughing. In this case, the woman is experiencing urine loss specifically when she sneezes, which aligns with the definition of stress incontinence. Other choices are incorrect because urinary frequency (choice A) refers to a frequent need to urinate, enuresis (choice B) is involuntary urination during sleep, and urge incontinence (choice D) is the sudden, strong need to urinate followed by involuntary leakage.
The first step in urine production
- A. is called reabsorption.
- B. moves water and solutes from the renal tubules into the peritubular capillaries.
- C. is called secretion.
- D. occurs as water and solutes move from the glomerulus to the glomerular capsul
Correct Answer: D
Rationale: The correct answer is D because the first step in urine production occurs as water and solutes move from the glomerulus to the glomerular capsule during the process of filtration. This initial step involves the passive movement of water and small solutes through the filtration membrane in the glomerulus. Reabsorption (choice A) occurs later in the process when useful substances are reclaimed from the filtrate. Choice B is incorrect as it describes the process of reabsorption, not the initial step. Choice C is also incorrect as secretion is the process of actively transporting substances from the blood into the renal tubules, not the first step in urine production.