HESI Maternal Newborn Related

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Which of the following is a fatal genetic neurologic disorder whose onset is in middle age?

  • A. Tay-Sachs disease
  • B. Duchenne muscular dystrophy
  • C. Hemophilia
  • D. Huntington's disease
Correct Answer: D

Rationale: Huntington's disease is a fatal genetic neurologic disorder characterized by progressive nerve cell degeneration in the brain. It typically manifests in middle age with symptoms such as involuntary movements, cognitive decline, and psychiatric disturbances. Tay-Sachs disease (Choice A) is a genetic disorder that primarily affects the nervous system in early childhood, not middle age. Duchenne muscular dystrophy (Choice B) is a genetic disorder that primarily affects muscle function and usually presents in early childhood. Hemophilia (Choice C) is a genetic disorder related to blood clotting, and its onset is not typically in middle age.