Nokea
Which of the following is not a type of anemia?
- A. Iron deficiency anemia
- B. Sickle cell anemia
- C. Aplastic anemia
- D. Diabetes
Correct Answer: D
Rationale: The correct answer is D: Diabetes. Anemia is a condition characterized by a lack of healthy red blood cells or hemoglobin. Diabetes does not directly cause anemia; it is a metabolic disorder affecting blood sugar levels. Iron deficiency anemia (A) is caused by a lack of iron, sickle cell anemia (B) is a genetic disorder affecting red blood cells, and aplastic anemia (C) is a bone marrow disorder. Therefore, the other choices are types of anemia, while diabetes is not.
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Which of the following statements is NOT true
- A. T cells expressing CD4 exert their function mainly through secretion of cytokines
- B. CD8 T cells interact with MHC class I molecules on antigen presenting cells
- C. CD4 T cells can help B cells because B cells express MHC class II molecules and can present antigen to T cells
- D. CD3 is not necessary for TCR signaling in cytotoxic T cells
Correct Answer: D
Rationale: The correct answer is D because CD3 is indeed necessary for TCR signaling in cytotoxic T cells. CD3 is a crucial component of the T cell receptor (TCR) complex, which is responsible for initiating intracellular signaling upon recognition of antigen-MHC complexes. Without CD3, TCR signaling cannot occur, leading to impaired T cell activation and cytotoxic function. Choices A, B, and C are incorrect because they accurately describe the functions and interactions of T cells expressing CD4 and CD8 with antigen presenting cells, as well as the role of CD4 T cells in helping B cells through antigen presentation.
Which of the statements below is NOT true. Integration is a stage of HIV life cycle that
- A. Utilizes a host enzyme called integrase
- B. Is a target of some anti-HIV drugs
- C. Allows duplication of proviral DNA when the infected cell divides
- D. Requires the formation of double stranded DNA
Correct Answer: A
Rationale: The correct answer is A. Integration is a stage of HIV life cycle that involves the insertion of viral DNA into the host cell's genome, facilitated by the enzyme integrase. To explain why A is incorrect, integrase is a viral enzyme, not a host enzyme.
B is correct as some anti-HIV drugs target the integration stage to prevent viral replication.
C is correct as integrated proviral DNA allows for duplication during cell division.
D is correct as integration requires the formation of double-stranded viral DNA.
Which of the following statements is NOT true
- A. The highest prevalence of HIV infection is found in Sub-Saharan Africa
- B. Vaccines using attenuated HIV virus are in a "phase II" clinical trial
- C. During the clinical latency of HIV infection the counts of CD4+ lymphocytes are progressively diminishing
- D. During the final stages of the disease the viral RNA titer is high
Correct Answer: B
Rationale: The correct answer is B because vaccines using attenuated HIV virus are not in a "phase II" clinical trial. Attenuated virus vaccines are risky due to potential reversion to virulence. A: True, Sub-Saharan Africa has the highest HIV prevalence. C: CD4+ counts decline during clinical latency. D: Viral RNA titer increases in the final stages.
The immunoglobulin Joining chain (J-chain) is
- A. only produced by T-Cells
- B. only produced by neutrophils
- C. associated with only multimeric forms of IgM and IgA
- D. associated with IgE for histamine release
Correct Answer: C
Rationale: Step-by-step rationale:
1. The J-chain is a polypeptide involved in the formation of polymeric IgM and IgA.
2. Polymeric forms of IgM and IgA contain the J-chain, aiding in their multimeric structure.
3. The J-chain is not exclusive to T-cells or neutrophils, making choices A and B incorrect.
4. IgE is associated with FcεRI receptors for histamine release, so choice D is incorrect.
Summary:
The correct answer is C because the J-chain is specifically associated with the multimeric forms of IgM and IgA, helping to form their structure. Choices A, B, and D are incorrect as the J-chain is not solely produced by T-cells, neutrophils, or associated with IgE for histamine release.
You obtain these assessment data while completing an admission for a patient with a history of a liver transplant who is receiving cyclosporine (Sandimmune),prednisone (Deltasone) and mycophenolate (CellCept) to suppress immune function. Which one will be of most concern?
- A. The patient’s gums appear very pink and swollen.
- B. The patient’s blood glucose is increased to 162 mg/dL.
- C. The patient has a non-tender swelling above the clavicle.
- D. The patient has 1+ pitting edema in the feet and ankles.
Correct Answer: C
Rationale: A non-tender swelling above the clavicle could indicate lymphadenopathy which may be a sign of infection or malignancy. This is particularly concerning in an immunocompromised patient. The other findings while important are less urgent and can be managed with standard nursing interventions.