Chronic Disease Questions Related

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Which of the following patients would probably not benefit from a >5-10% weight loss?

  • A. A 28-year-old female with BMI 37 kg/m² and oligomenorrhea but planning for fertility in the future
  • B. A 40-year-old man with BMI 26 kg/m², who has a strong family history of diabetes, recently diagnosed with prediabetes
  • C. A 21-year-old man with BMI 42 kg/m² with no known medical problems and a family history of T2DM
  • D. A 70-year-old female, BMI 26 kg/m², with well-controlled T2DM on two oral anti-diabetic medications and osteoporosis
Correct Answer: D

Rationale: A 5-10% weight loss benefits most with obesity-related conditions improving fertility (BMI 37), prediabetes (BMI 26), or T2DM risk (BMI 42). The 70-year-old with BMI 26, well-controlled T2DM, and osteoporosis may not benefit significantly; weight loss could worsen bone density, and her diabetes is managed, reducing urgency. Her age and comorbidities shift focus to stability, not weight reduction, guiding physicians in chronic care prioritization.