Roach's Introductory Clinical Pharmacology 11th Edition - Antidiabetic Drugs Related

Review Roach's Introductory Clinical Pharmacology 11th Edition - Antidiabetic Drugs related questions and content

Which of the following produce their glucose-lowering effect by decreasing insulin resistance and increasing insulin sensitivity?

  • A. Rosiglitazone (Avandia)
  • B. Metformin (Glucophage)
  • C. Pioglitazone (Actos)
  • D. Miglitol (Glyset)
  • E. Acarbose (Precose)
Correct Answer: A,C

Rationale: The thiazolidinediones, rosiglitazone (Avandia) and pioglitazone (Actos), produce their glucose-lowering effect by decreasing insulin resistance and increasing insulin sensitivity. The alpha-glucosidase inhibitors, acarbose (Precose) and miglitol (Glyset), produce their glucose-lowering effects by delaying the digestion and absorption of carbohydrates in the intestine. Metformin sensitizes the liver to circulating insulin levels and reduces hepatic glucose production.