NCLEX RN Exam Prep Related

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Which of the following statements best describes substance P?

  • A. Substance P decreases a client's sensitivity to pain
  • B. Substance P levels are drawn before administration of narcotic analgesics
  • C. Substance P is found in the brain and is responsible for pain control and management of depression
  • D. Substance P is found in the dorsal horn of the spinal column
Correct Answer: D

Rationale: Substance P is a neurotransmitter found in the brain and the dorsal horn of the spinal column, not just in the brain. It is associated with pain transmission and modulation. Substance P is known to cause inflammation, edema, and pain. While it plays a role in pain perception, it does not decrease a client's sensitivity to pain (Choice A), nor are its levels typically drawn before administering narcotic analgesics (Choice B). Although substance P is involved in pain control, it is not responsible for managing depression (Choice C). Therefore, the correct statement is that substance P is found in the dorsal horn of the spinal column.