Nokea
Which of the following statements is FALSE regarding B cells?
- A. B cells that recognize high concentrations of antigen (self) in the absence of other signals undergo apoptosis in the bone marrow
- B. Bone marrow stem cells migrate to the thymus and develop into B cells
- C. B cells synthesize antibodies and put them on their cell surface
- D. B cells can undergo class switching and produce a different antibody type
Correct Answer: B
Rationale: B cells develop in the bone marrow, not the thymus. Firstly, hematopoietic stem cells in the bone marrow give rise to B cells. They undergo maturation and selection processes in the bone marrow, not in the thymus. Therefore, choice B is false. On the other hand, choices A, C, and D are correct. A is true because B cells with high affinity to self-antigens undergo apoptosis to prevent autoimmunity. C is true since B cells synthesize antibodies which can be displayed on their surface as B cell receptors. D is true because B cells can undergo class switching to produce different types of antibodies based on the immune response requirements.
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A patient suffering form tuberculosis was treated with rifampicin, which caused drug resistance of tuberculosis mycobacteria. In order to reduce mycobacteria resistance, rifampicin should be combined with the following drug:
- A. Isoniazid
- B. Acyclovir
- C. Intraconazole
- D. Metronidazole
Correct Answer: A
Rationale: The correct answer is A: Isoniazid. When rifampicin is used alone, there is a risk of developing resistance. Isoniazid is commonly used in combination with rifampicin to prevent resistance by targeting different mechanisms in the bacteria. Isoniazid works by inhibiting mycolic acid synthesis, while rifampicin targets RNA polymerase. This combination therapy is known as the first-line treatment for tuberculosis. Choices B, C, and D are incorrect because they do not have the same mechanism of action as isoniazid and would not be effective in preventing rifampicin resistance.
Which of the following bacteria is known for producing a biofilm on medical devices?
- A. Clostridium tetani
- B. Pseudomonas aeruginosa
- C. Salmonella enterica
- D. Staphylococcus aureus
Correct Answer: B
Rationale: The correct answer is B: Pseudomonas aeruginosa. This bacterium is known for producing biofilms on medical devices due to its ability to adhere and form a slimy layer that protects it from antibiotics and the host immune system. Pseudomonas aeruginosa is commonly associated with healthcare-associated infections.
Clostridium tetani (A) causes tetanus, not known for biofilm production on medical devices. Salmonella enterica (C) causes foodborne illnesses, not typically associated with medical device biofilms. Staphylococcus aureus (D) is a common pathogen in healthcare settings but is not specifically known for biofilm production on medical devices.
Enriched growth media:
- A. Belong to the minimal media and inhibit the development of gram+ cocci
- B. Support the development of the target bacteria groups without suppressing the growth of other microorganisms
- C. Are intended for the cultivation of only one microbial species
- D. Support the development of target bacteria groups and suppress the development of other microorganisms
Correct Answer: B
Rationale: The correct answer is B because enriched growth media provide essential nutrients that support the growth of target bacteria groups without inhibiting the growth of other microorganisms. This allows for the selective cultivation of specific microbes while still allowing for the growth of other organisms present in the sample. Choice A is incorrect because enriched media do not belong to minimal media and do not inhibit the development of gram+ cocci. Choice C is incorrect because enriched media can support the growth of multiple microbial species. Choice D is incorrect because enriched media do not suppress the development of other microorganisms but rather provide nutrients to support their growth alongside the target bacteria groups.
Which type of bacteria can survive in extreme salty environments?
- A. Psychrophiles
- B. Halophiles
- C. Thermophiles
- D. Mesophiles
Correct Answer: B
Rationale: The correct answer is B: Halophiles. Halophiles are bacteria that can survive in extreme salty environments. They have adapted to thrive in high salt concentrations. Psychrophiles (A) thrive in cold temperatures, Thermophiles (C) thrive in high temperatures, and Mesophiles (D) thrive in moderate temperatures. Therefore, they are not adapted to survive in extreme salty environments like Halophiles.
Gram-positive spore-forming bacilli were extracted in anoxic environment from the patient's wound contaminated with soil. Cultivation on a blood-glucose agar resulted in growth of the colonies surrounded with hemolysis zone. What agent was extracted from the wound?
- A. Clostridium perfringens
- B. Clostridium botulinum
- C. Staphylococcus aureus
- D. Pseudomonas aeruginosa
Correct Answer: A
Rationale: The correct answer is A: Clostridium perfringens. Clostridium perfringens is a gram-positive spore-forming bacillus commonly found in soil. It produces hemolysis on blood agar, as described in the question. Clostridium botulinum is also a gram-positive spore-forming bacillus, but it does not typically cause hemolysis. Staphylococcus aureus is a gram-positive cocci, not a bacillus. Pseudomonas aeruginosa is a gram-negative bacterium, not a gram-positive spore-forming bacillus.