Nokea
Which one of the following statements is NOT true of warfarin?
- A. It is extensively 99% bound to plasma albumin
- B. Its use in pregnant women is contraindicated because it is teratogenic
- C. It is active in vitro
- D. Its induced bleeding can be conteracted by treatment with phytonadione
Correct Answer: C
Rationale: Warfarin acts in vivo by inhibiting vitamin K epoxide reductase, not in vitro; thus, is false.
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Which of the following statement is correct for Amantadine?
- A. Has agonistic action on NDMA type of glutamate receptors
- B. It was developed as antiepileptic drug
- C. Acts as a D2 blocker
- D. Produces livedo reticularis as side effect
Correct Answer: D
Rationale: Amantadine, an antiviral and antiparkinsonian drug, can cause livedo reticularis (a skin mottling side effect); it blocks NMDA receptors, not agonizes them, and enhances dopamine release, not blocks D2.
Which of the following measuring systems used in drug preparation and delivery uses the gram as the basic unit of solid measure?
- A. Metric system
- B. Apothecary system
- C. Household system
- D. Avoirdupois system
Correct Answer: A
Rationale: The metric system is the most widely used system of measurement and is based on the decimal system. The gram is the basic unit of solid measure and the liter is the basic unit of liquid measure. The apothecary system uses the grain as the basic unit of solid measure. The household system uses the pound as the basic unit of measure. The avoirdupois system uses ounces and grains but is mostly used by drug manufacturers for bulk medications.
The nurse promotes optimal drug effectiveness by doing what? (Select one that does not apply.)
- A. Incorporate basic history and physical assessment factors into the plan of care.
- B. Evaluate the effectiveness of drugs after they have been administered.
- C. Modify the drug regimen to modify adverse or intolerable effects.
- D. Minimize the number of medications administered to patients.
Correct Answer: D
Rationale: Incorporate basic history and physical assessment factors into any plan of care so that obvious problems can be identified and handled promptly. If a drug simply does not do what it is expected to do, further examine the factors that are known to influence drug effects. Frequently, the drug regimen can be modified to deal with that influence. Minimizing the number of medications administered is usually not an option because each drug is ordered for a reason of necessity for the patient.
The following can be used for diabetes mellitus:
- A. Desmoporesine
- B. Insuline preparations
- C. Chlorpropamide
- D. Metformin
Correct Answer: A
Rationale: Insulin, chlorpropamide, metformin, and acarbose (B, C, D, E) are all used for diabetes management.
Your patient calls for an appointment before going on vacation. Which medication should you ensure he has an adequate supply of before leaving to avoid life-threatening complications?
- A. Carvedilol
- B. Donepezil
- C. Bethanechol
- D. Tacrine
Correct Answer: A
Rationale: Abrupt carvedilol withdrawal can cause life-threatening rebound hypertension or ischemia.