Pathophysiology Practice Questions Related

Review Pathophysiology Practice Questions related questions and content

Which pathophysiologic process causes the decreased glomerular filtration rate in a patient with acute glomerulonephritis?

  • A. Decreased renal-induced constriction of the renal arteries
  • B. Immune complex deposition, increased capillary permeability, and cellular proliferation
  • C. Necrosis of 70% or more of the nephrons secondary to increased kidney interstitial hydrostatic pressure
  • D. Scar tissue formation throughout the proximal convoluted tubule secondary to toxin-induced collagen synthesis
Correct Answer: B

Rationale: The correct answer is B: Immune complex deposition, increased capillary permeability, and cellular proliferation. In acute glomerulonephritis, immune complexes deposit in the glomerulus, leading to inflammation, increased capillary permeability, and cellular proliferation. These processes collectively reduce the glomerular filtration rate. Choices A, C, and D do not accurately describe the pathophysiologic process in acute glomerulonephritis. Decreased renal-induced constriction of the renal arteries, necrosis of nephrons due to increased kidney interstitial hydrostatic pressure, and scar tissue formation in the proximal convoluted tubule are not the primary mechanisms responsible for the decreased filtration rate in this condition.