Nokea
While taking an angiotensin II receptor blocker (ARB), patients need to avoid certain over-the-counter drugs without first consulting the provider because:
- A. Cimetidine is metabolized by the CYP 3A4 isoenzymes
- B. Nonsteroidal anti-inflammatory drugs reduce prostaglandin levels
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: B
Rationale: NSAIDs reduce prostaglandins, counteracting ARB's renal protective effects.
You may also like to solve these questions
The nursing students are learning about the half-life of drugs. A student asks the instructor to explain half-life. What is the instructor's best response?
- A. Half-life of a drug is the time it takes for the amount of drug in the body to decrease to half of the peak level it previously achieved.
- B. Half-life is the amount of time it takes for the drug to be metabolized by the body.
- C. Half-life is the amount of time it takes for half of the drug to reach peak level in the body.
- D. Half-life of a drug is the time it takes for the drug to reach half its potential peak level in the body.
Correct Answer: A
Rationale: The half-life of a drug is the time it takes for the amount of drug in the body to decrease to half the peak level it previously achieved. Therefore Options B, C, and D are not correct.
Which of the following statements best defines how a chemical becomes a drug?
- A. A chemical must have a proven therapeutic value or efficacy without severe toxicity or damaging properties to become a drug.
- B. A chemical becomes a drug when it is introduced into the body to cause a change.
- C. A chemical is considered a drug when the Food and Drug Administration (FDA) approves its release to be marketed.
- D. A chemical must have demonstrated therapeutic value to become a drug.
Correct Answer: A
Rationale: A chemical must undergo a series of tests to determine its therapeutic value and efficacy without severe toxicity or damaging properties before it is termed a drug. Test results are reported to the FDA, which may or may not give approval.
The patient is prescribed a medication that was just placed in Phase IV study. The patient tells the nurse, This medication is too expensive. Could the doctor order a generic form of this medication? What is the nurses most accurate response?
- A. Medications are not produced in generic form until the patent expires, which normally takes several years.
- B. You can request the generic form but the binder used may make the drug less effective for this medication.
- C. The generic form of the medication would not be any less expensive because this is a relatively new medication.
- D. Generic medications are lower quality drugs and that would mean you would not be getting the best treatment available.
Correct Answer: A
Rationale: When a new drug enters the market, it is given a time-limited patent; generic forms of the medication cannot be produced until the patent expires. Because no generic version of this drug will exist because it is so new, it is impossible to predict what binder will be used or what the cost would be.
A patient with asthma has been using a nicotine transdermal 24-hour patch for 3 weeks to quit smoking. The patient reports having difficulty sleeping. What action will the nurse take?
- A. Ask the provider for a prescription for Nicotrol NS
- B. Recommend removing the patch at bedtime
- C. Suggest using an 18-hour patch instead
- D. Tell the patient to stop the patch and join a support group
Correct Answer: C
Rationale: An 18-hour patch reduces sleep disruption while aiding cessation; Nicotrol is risky with asthma. The patient should try an 18-hour patch to help with sleep.
When assessing a patient prior to starting a drug regimen it is often necessary to have a baseline kidney function study done. What might kidney impairment indicate in relation to drug therapy?
- A. Pharmacodynamics stable at the therapeutic dose
- B. Contraindication to the use of a drug
- C. Increased dosage of a drug
- D. Decreased adverse effects of a drug
Correct Answer: B
Rationale: Kidney impairment may contraindicate certain drugs due to reduced clearance, risking toxicity.