Nokea
Ultra-rapid metabolizers of drugs may have:
- A. To have dosages of drugs adjusted downward to prevent drug accumulation
- B. Active drug rapidly metabolized into inactive metabolites, leading to potential therapeutic failure
- C. Increased elimination of active, nonmetabolized drug
- D. Slowed metabolism of a prodrug into an active drug, leading to an accumulation of prodrug
Correct Answer: B
Rationale: Ultra-rapid metabolizers (e.g., CYP2D6) quickly inactivate drugs , risking therapeutic failure, requiring higher doses, not lower or slowed metabolism .
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The patient tells the nurse about a new drug being tested to treat the disease she was diagnosed with and asks the nurse whether the doctor can prescribe a medication still in the preclinical phase of testing. What is the nurse's best response?
- A. The doctor would have to complete a great deal of paperwork to get approval to prescribe that drug.
- B. Sometimes pharmaceutical companies are looking for volunteers to test a new drug and the doctor could give them your name.
- C. Drugs in the preclinical phase of testing are only tested on animals and so would not be available to you.
- D. Drugs in the preclinical phase of testing are given only to healthy young men and so would not be available to you.
Correct Answer: C
Rationale: During the preclinical phase of testing drugs are tested on animals and are not available to patients. In phase I, the drug is tested on volunteers who are usually healthy young men. It is only in phase III studies that the drug is made available to prescribers who agree to closely monitor patients getting the medication.
A nurse is caring for a client who is receiving daily doses of Oprelvekin. Which of the following laboratory values should the nurse monitor to determine effectiveness of this medication?
- A. Hemoglobin
- B. Absolute neutrophil count
- C. Platelet count
- D. Total white blood count
Correct Answer: C
Rationale: Oprelvekin increases platelet count , its primary therapeutic effect.
The drug used for the treatment of trachomoniasis is:
- A. Tetracycline
- B. Suramin
- C. Metronidazole
- D. Pyrimethamine
Correct Answer: C
Rationale: Metronidazole is the standard treatment for trichomoniasis, a protozoal infection caused by Trichomonas vaginalis, due to its specific antiprotozoal activity.
Which of the following drugs do not cross the placenta
- A. Dilantin
- B. Diazepam
- C. Acinocoumarin
- D. Heparin
Correct Answer: D
Rationale: Heparin does not cross the placenta due to its large size.
Which statement is correct regarding glucagon:
- A. Causes hypoglicemia
- B. Causes hyperglicemia
- C. Haven't affect blood glucose level in blood
Correct Answer: B
Rationale: Glucagon causes hyperglycemia by stimulating glycogenolysis and gluconeogenesis in the liver.