Nokea
Avoid concurrent administration of exenatide with which of the following drugs?
- A. Digoxin
- B. Warfarin
- C. Lovastatin
- D. All of the above
Correct Answer: D
Rationale: Exenatide delays gastric emptying, potentially affecting absorption of digoxin , warfarin , and lovastatin .
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Ultra-rapid metabolizers of drugs may have:
- A. To have dosages of drugs adjusted downward to prevent drug accumulation
- B. Active drug rapidly metabolized into inactive metabolites, leading to potential therapeutic failure
- C. Increased elimination of active, nonmetabolized drug
- D. Slowed metabolism of a prodrug into an active drug, leading to an accumulation of prodrug
Correct Answer: B
Rationale: Ultra-rapid metabolizers (e.g., CYP2D6) quickly inactivate drugs , risking therapeutic failure, requiring higher doses, not lower or slowed metabolism .
Which of the following produced by the pancreatic alfa cells:
- A. Insulin
- B. Glucagon
- C. C-peptide
- D. Somatostatin
Correct Answer: B
Rationale: Glucagon is produced by pancreatic alpha cells to raise blood glucose.
Felicity has been prescribed colestipol to treat her hyperlipidemia. Unlike other anti-lipidemics, this drug:
- A. Blocks synthesis of cholesterol in the liver
- B. Exchanges chloride ions for negatively charged acids in the bowel
- C. Increases HDL levels the most among the classes
- D. Blocks the lipoprotein lipase pathway
Correct Answer: B
Rationale: Colestipol, a bile acid resin, binds bile acids in the bowel.
Which of the following drugs do not cross the placenta
- A. Dilantin
- B. Diazepam
- C. Acinocoumarin
- D. Heparin
Correct Answer: D
Rationale: Heparin does not cross the placenta due to its large size.
Slow channel syndrome is due to
- A. Accumulation of Na+ ions in channels
- B. Accumulation of K+ ions in channels
- C. Accumulation of Mg++ ions in channels
- D. Accumulation of Ca++ ions in channels
Correct Answer: D
Rationale: Slow channel syndrome relates to calcium channel dysfunction.