Nokea
Education of women who are being treated with ophthalmic antibiotics for conjunctivitis includes:
- A. Throwing away eye makeup and purchasing new
- B. Redness and intense burning is normal with ophthalmic antibiotics
- C. When applying eye ointment, set the tip of the tube on the lower lid and squeeze in 1/4 inch
- D. Use a cotton swab to apply ointment, spreading the ointment all over the lid and in the conjunctival sac
Correct Answer: A
Rationale: Discarding makeup prevents reinfection; burning isn't normal, and application is incorrect.
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All the following induce hepatic enzymes except
- A. Rifampicin
- B. Phenytoin
- C. Barbiturates
- D. Tolbutamide
Correct Answer: D
Rationale: Tolbutamide does not significantly induce enzymes; others do.
A 66-year-old man is admitted to the hospital with confusion, nausea, and blurred vision. He is currently on digoxin for the treatment of heart failure. On physical exam, his heart rate is 120 bpm. Further evaluation reveals a digoxin level of 5.3 ng/mL (normal range: 0.5-2 ng/mL). The doctor believes his symptoms are due to digoxin toxicity. Which parameter is used to indicate the ability of digoxin to produce the desired effect relative to a toxic effect?
- A. Bioavailability
- B. Efficacy
- C. Intrinsic activity
- D. Therapeutic index
Correct Answer: D
Rationale: Therapeutic index (TI) measures the relative safety of a drug by comparing the dose required for a therapeutic effect to the dose that produces toxicity. In this case, digoxin toxicity is indicated by the elevated level, and TI is the relevant parameter.
Where would the procedures and treatments directed by the health care provider be found?
- A. Summary sheet
- B. Physician's order form
- C. Physician's progress notes
- D. History and physical examination form
Correct Answer: B
Rationale: The physician's order form contains all procedures and treatments ordered by the health care provider. A summary sheet provides a brief overview of the hospital course at discharge. Physician's progress notes provide regular observations on the patient's course of treatment and response. A history and physical examination form provides information about baseline information from the patient.
Chlorpropamide metabolism is enhanced by
- A. Ethyl alcohol
- B. Diazepam
- C. Lorazepam
- D. Chloridazepoxide
Correct Answer: A
Rationale: Ethyl alcohol induces hepatic enzymes, enhancing the metabolism of chlorpropamide, a sulfonylurea antidiabetic drug.
Food can alter the pH of the stomach, leading to:
- A. Enhanced drug metabolism
- B. Altered vitamin K absorption
- C. Increased vitamin D absorption
- D. Altered drug bioavailability
Correct Answer: D
Rationale: Changes in stomach pH due to food can affect drug dissolution and absorption, altering bioavailability.