Nokea
Severe combined immunodeficiency (SCID) is a disease caused by:
- A. Infection with human immunodeficiency virus
- B. One of several inherited genetic mutations
- C. Deficiency of both innate and adaptive immune components
- D. Deficiency of hematopoietic stem cells
Correct Answer: B
Rationale: Step 1: SCID is a genetic disorder affecting the immune system.
Step 2: Inherited genetic mutations cause abnormalities in immune cells.
Step 3: These mutations lead to severe deficiencies in immune function.
Step 4: Choice B accurately reflects the genetic basis of SCID.
Summary: Choice A is incorrect because SCID is not caused by HIV. Choice C is incorrect as it oversimplifies the immune deficiencies in SCID. Choice D is incorrect because SCID primarily affects immune cells, not stem cells.
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What condition is associated with C1q deficiency?
- A. Cancer
- B. Systemic lupus erythematosus (SLE)
- C. HIV/AIDS
- D. Chronic obstructive pulmonary disease
Correct Answer: B
Rationale: Rationale: C1q is a component of the classical complement pathway, crucial for immune complex clearance. Its deficiency is associated with SLE due to impaired immune complex removal, leading to autoantibody deposition and inflammation. Cancer, HIV/AIDS, and COPD are not directly linked to C1q deficiency.
Where do T cells mature?
- A. Bone marrow
- B. Thymus
- C. Spleen
- D. Lymph nodes
Correct Answer: B
Rationale: The correct answer is B: Thymus. T cells mature in the thymus, where they undergo selection and maturation processes essential for their function in the immune system. The thymus provides a specialized environment for T cell development, including positive and negative selection to ensure self-tolerance and functional T cell repertoire.
A: Bone marrow is incorrect because it is the site of B cell maturation, not T cells.
C: Spleen is incorrect as it acts as a secondary lymphoid organ for immune response but not the site of T cell maturation.
D: Lymph nodes are incorrect as they are important for immune surveillance and activation but not the primary site for T cell maturation.
A patient is admitted with acute myelogenous leukemia and a history of Hodgkin’s lymphoma. What is the nurse likely to find in the patient’s history?
- A. Work as a radiation chemist
- B. Epstein-Barr virus diagnosed in vitro
- C. Intense tanning throughout the lifetime
- D. Alkylating agents for treating the Hodgkin’s lymphoma
Correct Answer: D
Rationale: Alkylating agents used to treat Hodgkin’s lymphoma can increase the risk of developing secondary malignancies like acute myelogenous leukemia.
Which of the following statements is NOT true?
- A. Plague or Black Death is the disease that devastated Europe in Medieval times (1350-1400) with about 50% of the European population having been wiped out.
- B. There are reports of Black Death dating as early as 1000 B.C. making plague probably the most ancient disease and the first recorded
- C. Plague is still endemic in some countries
- D. Plague can be cured with antibiotics
Correct Answer: B
Rationale: The correct answer is B because there are no reports of the Black Death dating back to 1000 B.C. The Black Death specifically refers to the pandemic outbreak of the bubonic plague in the 14th century. The first recorded pandemic of the Black Death occurred in the 14th century, not in 1000 B.C. The other choices are incorrect because A is true as the Black Death did devastate Europe in the 14th century, C is true as plague is still present in some countries, and D is true as plague can be treated with antibiotics if caught early.
Compared to antibodies produced in a primary response to a given antigen, the antibodies produced in a memory response are typically:
- A. More likely to be IgM
- B. More likely to be IgG, IgA and/or IgE
- C. Of lower affinity
- D. Two of these responses are correct
Correct Answer: B
Rationale: Step 1: Memory response produces antibodies of higher affinity due to affinity maturation.
Step 2: Memory response involves class switching, leading to production of IgG, IgA, and IgE.
Step 3: IgM is predominant in primary response, but memory response shifts towards other classes.
Summary: Choice B is correct as memory response produces antibodies of higher affinity and different classes. Choices A and C are incorrect as memory response does not typically result in more IgM or lower affinity antibodies. Choice D is incorrect as only choice B is accurate.