Genitourinary System Quizlet Related

Review Genitourinary System Quizlet related questions and content

A 35 year old man heroin addict on methadone maintenance therapy for the last one year, is positive for TB on Chest x-ray. He was started on standard quadri anti-TB drug. He is rushed to ER complaining of withdrawal symptoms. Which of the following anti-TB drugs is likely to cause this patient’s withdrawal reaction?

  • A. Streptomycin
  • B. Rifampicin
  • C. INH
  • D. Pyrazinamide
Correct Answer: B

Rationale: The correct answer is B: Rifampicin. Rifampicin is known to induce cytochrome P450 enzymes, leading to increased metabolism of methadone and subsequently causing withdrawal symptoms in methadone-maintained patients. Streptomycin (A) is an aminoglycoside antibiotic used in TB treatment but does not interact with methadone. INH (C) and Pyrazinamide (D) do not have significant interactions with methadone metabolism. Therefore, Rifampicin is the likely cause of this patient's withdrawal symptoms.