Nokea
A 49-year-old woman with a history of hypertension is treated with spironolactone. She has good blood pressure control and in the last 6 months has shown an improvement in her hirsutism. What is the most likely explanation for these findings?
- A. Androgen receptor inhibition of the hair follicle
- B. Drug toxicity
- C. Hypoaldosteronism
- D. Testosterone levels are elevated
Correct Answer: A
Rationale: Spironolactone's anti-androgenic effects inhibit androgen receptors, reducing hirsutism, alongside its aldosterone antagonism for hypertension.
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An important concept taught by the nurse when providing medication teaching is the need to provide a complete list of medications taken to health care providers to avoid what?
- A. Spending large amounts of money on medications
- B. Allergic reactions to medications
- C. Drug-drug interactions
- D. Critical concentrations of medications in the body
Correct Answer: C
Rationale: It is important that all health care providers have a complete list of the patients medications to avoid drug-drug interactions caused by one provider ordering a medication, unaware of another medication the patient is taking that could interact with the new prescription. Using the same pharmacist for all prescriptions will also help to prevent this from happening. Informing the provider of all medications taken will not reduce costs of medications, which is best accomplished by requesting generic medications. Allergies should be disclosed to all health care providers as well, but this is not why it is important to provide a complete list of medications taken. Critical concentrations are desirable because that is the amount of drug needed to cause a therapeutic effect, or, in other words, to have the effect the drug is prescribed for.
When taken with aminoglycosides, platinum chemotherapy or cyclosporin increase the risk of
- A. Kidney damage
- B. Ototoxicity
Correct Answer: A
Rationale: Platinum chemotherapy (e.g., cisplatin) and cyclosporin both potentiate aminoglycoside nephrotoxicity, increasing kidney damage risk.
A nurse is reviewing the medical record of a client and notes the various orders for drug therapy. Which of the following would the nurse most likely expect to find? (Select one that does not apply.)
- A. Standing order
- B. STAT order
- C. Single order
- D. Alternate order
Correct Answer: D
Rationale: Common orders given by health care providers for drug therapy include the standing order, the single order, the PRN order, and the STAT order.
When taking a medication history on a patient why should the nurse ask about the use of complementary or alternative therapies?
- A. Patients starting on new drugs are usually not compliant with medical regimens.
- B. Many drug-alternative therapy interactions can cause serious problems.
- C. Natural products may be more effective and the prescribed drug may not be needed.
- D. The cost of the drug and the alternative therapy may be too expensive for the patient to hand
Correct Answer: B
Rationale: Complementary therapies can interact with prescribed drugs, posing risks that the nurse must identify.
A patient who is taking isoniazid (INH) as part of a two-drug tuberculosis treatment regimen reports tingling of the fingers and toes. The nurse will recommend discussing which treatment with the provider?
- A. Adding pyrazinamide
- B. Changing to ethambutol
- C. Increasing oral fluid intake
- D. Taking pyridoxine (B6)
Correct Answer: D
Rationale: Pyridoxine prevents INH-induced neuropathy (tingling); changing drugs or fluids doesn't address this. Peripheral neuropathy is an adverse reaction to INH, so pyridoxine is usually given to prevent this.