Nokea
A client comes to the clinic complaining of muscle aches and asks the nurse about using an over-the-counter NSAID. The client tells the nurse that he takes a medication to control his high blood pressure. The nurse cautions the client against using an NSAID while on antihypertensive drug therapy for which reason?
- A. It increases the metabolism of the antihypertensive drug.
- B. It increases absorption of the antihypertensive drug.
- C. It decreases the effectiveness of the antihypertensive drug.
- D. It decreases the metabolism of NSAIDs.
Correct Answer: C
Rationale: The nurse should inform the patient that taking an NSAID while on antihypertensive drug therapy decreases the effectiveness of antihypertensive drugs. Interactions of NSAIDs and antihypertensive drugs do not include increased metabolism of antihypertensive drugs, increased absorption of antihypertensive drugs, or decreased metabolism of NSAIDs.
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A nursing instructor is preparing a class discussion on the use of NSAIDs and interactions with other drugs. The instructor would emphasize that the effects of which of the following can increase with NSAID therapy? Select all that apply.
- A. Lithium
- B. Cyclosporine
- C. Furosemide
- D. Lisinopril
- E. Phenytoin
Correct Answer: A,B,E
Rationale: The use of NSAIDs can increase the effectiveness of lithium, cyclosporine, and phenytoin, possibly leading to toxicity.
A client is prescribed frovatriptan. Which of the following would the nurse expect to include in the client's teaching plan? Select all that apply.
- A. Frovatriptan is used to prevent migraines.
- B. Frovatriptan should be administered at the earliest onset of migraine symptoms.
- C. Frovatriptan will decrease the number of migraine headaches experienced.
- D. No more than two doses of the drug should be used in a 24-hour period.
- E. The dose of frovatriptan may be repeated every hour until symptoms subside.
Correct Answer: B,D
Rationale: Frovatriptan does not prevent migraines or reduce the number of migraines. If should be taken at the earliest onset of migraine symptoms and the dose may be repeated one time after 1 hour if no relief is obtained. The client should never take more than two doses of frovatriptan in a 24-hour period.
A nurse is describing the actions of NSAIDs to a client. Which of the following would the nurse integrate into the description as a mechanism by which NSAIDs elicit their effects? Select all that apply.
- A. Inhibition of prostaglandins
- B. Inhibition of cyclooxygenase-1
- C. Synthesis of cyclooxygenase-2
- D. Synthesis of cyclooxygenase-3
- E. Inhibition of platelet aggregation
Correct Answer: A,B,C
Rationale: NSAIDs exert their effects by inhibition of prostaglandin synthesis via inhibition of cyclooxygenase-1 and -2.
The nurse would question an order for a selective serotonin agonist as treatment for a migraine headache for a client with which condition? Select all that apply.
- A. Diabetes
- B. Uncontrolled hypertension
- C. Angina
- D. Hyperlipidemia
- E. Transient ischemic attacks
Correct Answer: B,C,E
Rationale: 5-HT agonists should not be used in patients with ischemic heart disease (such as angina or myocardial infarction), transient ischemic attacks (TIA), uncontrolled hypertension, or those patients taking monoamine oxidase inhibitor (MAOI) antidepressants.
When describing the properties of ibuprofen to a group of individuals attending a community health promotion presentation, the nurse would integrate knowledge of which of the following? Select all that apply.
- A. Anti-inflammatory
- B. Analgesic
- C. Antipruritic
- D. Antipyretic
- E. Antibacterial
Correct Answer: A,B,D
Rationale: Like the salicylates, the NSAIDS have anti-inflammatory, antipyretic, and analgesic effects. They do not exert antipruritic or antibacterial properties.