Nokea
A client is receiving Cefotaxime IV for a severe infection. Which finding indicates a potentially serious adverse reaction to this medication that the nurse should report to the provider?
- A. Diaphoresis
- B. Epistaxis
- C. Diarrhea
- D. Alopecia
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
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A nurse is teaching a client who has a prescription for a long-term use of oral prednisone for chronic asthma. The nurse should instruct the client to monitor for which of the following adverse effects?
- A. Weight Gain
- B. Nervousness
- C. Bradycardia
- D. Constipation
Correct Answer: A
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
A 44-year-old man who is a chronic smoker and takes bupropion takes 10 pills at once in an attempted suicide. Which of the following effects is possible as a result of this overdose?
- A. Dry mouth
- B. Nervousness
- C. Seizures
- D. Sexual dysfunction
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
When administering the drug lithium, what is one important side effect to watch for?
- A. Anaphylaxis
- B. Seizures
- C. Angioedema
- D. Pulmonary Edema
Correct Answer: C
Rationale: When administering lithium, it is crucial to watch for the side effect of angioedema. Angioedema is a potential adverse reaction associated with lithium therapy, characterized by rapid swelling beneath the skin, often around the eyes and lips. Monitoring for this side effect is essential to promptly address and manage any signs of angioedema that may occur during lithium treatment.
A client is receiving Enoxaparin for the prevention of deep vein thrombosis. Which of the following actions should the nurse take?
- A. Massage the injection site after administration.
- B. Administer the medication intramuscularly.
- C. Administer the medication into the subcutaneous tissue.
- D. Administer the medication into the deltoid muscle.
Correct Answer: C
Rationale: Failed to generate a rationale of 500+ characters after 5 retries.
Individuals who are slow acetylators (i.e. have a relatively low activity of hepatic N-acetyltransferase):
- A. Have a prevalence of 15-20 per cent in European caucasians
- B. Are more likely to develop thrombocytopenia, nephrotic syndrome and rash during gold treatment
- C. Are more likely to develop hepatotoxicity following halothane anaesthesia
- D. Are more likely to develop antinuclear antibodies during hydralazine therapy
Correct Answer: D
Rationale: Slow acetylators have reduced hepatic N-acetyltransferase (NAT2) activity, affecting metabolism of drugs like hydralazine, isoniazid, and procainamide. In European Caucasians, prevalence is actually 50-60%, not 15-20%, making that statement inaccurate. Gold treatment side effects like thrombocytopenia or nephrotic syndrome aren't strongly linked to acetylation status, but rather to immune responses, so that's less relevant. Halothane hepatotoxicity relates to immune-mediated reactions or metabolites, not acetylation speed. Hydralazine, metabolized by NAT2, accumulates in slow acetylators, increasing risk of drug-induced lupus with antinuclear antibodies (ANA), a well-documented association. Agranulocytosis with clozapine isn't tied to acetylation but to idiosyncratic reactions. The ANA risk with hydralazine is the most accurate, reflecting its pharmacogenetic implications, critical for personalized dosing and monitoring.