Roach's Introductory Clinical Pharmacology 11th Edition - Cholinesterase Inhibitors Related

Review Roach's Introductory Clinical Pharmacology 11th Edition - Cholinesterase Inhibitors related questions and content

A client is receiving donepezil. When reviewing the client's medication history, the nurse determines that the client is at increased risk for GI bleeding if the client is also taking which drug?

  • A. Naproxen (Naprosyn)
  • B. Oxycodone (OxyContin)
  • C. Acetaminophen (Tylenol)
  • D. Ibuprofen (Motrin)
  • E. Meperidine (Demerol)
Correct Answer: A,D

Rationale: Use of nonsteroidal anti-inflammatory drugs (NSAIDs), such as naproxen or ibuprofen, in combination with donepezil place the client at an increased risk for GI bleeding. Oxycodone, acetaminophen, and meperidine do not increase the client's risk.