Nokea
A client is receiving pravastatin to reduce the risk of coronary heart disease due to hyperlipidemia. The client is also receiving amiodarone for an arrhythmia. The nurse understands that the client is at risk for which of the following based on these two drugs?
- A. Increased anticoagulant effect
- B. Increased hypoglycemic effect
- C. Increased risk of myopathy
- D. Decreased effects of pravastatin
Correct Answer: C
Rationale: When the HMG-CoA reductase inhibitor pravastatin is administered with amiodarone, the nurse should monitor the client for increased risk of myopathy as an effect of the interaction between the two drugs. Increased anticoagulant effect is observed in clients receiving warfarin along with pravastatin. Increased hypoglycemic effects are observed in clients receiving sulfonylureas with fibric acid derivatives. The interaction of pravastatin with amiodarone does not decrease the effect of pravastatin.
You may also like to solve these questions
Prior to administering an antihyperlipidemic drug to a client, which of the following would the nurse assess?
- A. Dietary history
- B. Vital signs
- C. Blood glucose
- D. Weight
- E. Input and output
Correct Answer: A,B,D
Rationale: Before administering an antihyperlipidemic drug, the nurse would assess a lipid profile, liver function tests, dietary history, vital signs, and weight and inspect for xanthomas.
The nurse is reviewing a client's medical record for predisposing factors for myopathy requiring that the client be started on low doses of statins and titrated as tolerated or until cholesterol goals are met. Which of the following would the nurse identify as one of these factors?
- A. Asian descent
- B. Severe renal insufficiency
- C. Use of antihistamines
- D. Use of cyclosporine
- E. Cigarette smoking
Correct Answer: A,B,D
Rationale: Predisposing factors for myopathy with statin therapy include Asian descent, severe renal insufficiency, and use of cyclosporine.
A nurse is reviewing a client's laboratory test results after being on statin therapy for several months. Which of the following would the nurse interpret as indicating effectiveness of the drug?
- A. Total cholesterol 220 mg/dL
- B. LDL cholesterol 80 mg/dL
- C. HDL cholesterol 30 mg/dL
- D. LDL cholesterol 165 mg/dL
- E. HDL cholesterol 60 mg/dL
Correct Answer: B,E
Rationale: Effectiveness of therapy would be indicated by values that are low or optimal. This would include a total cholesterol below 200 mg/dL, LDL less than 100 mg/dL, and HDL greater than 40 mg/dL.
Which of the following would the nurse include in the client teaching about HMG-CoA reductase inhibitors (statins)?
- A. Photosensitivity can occur
- B. The drug should be continued even if the client feels better
- C. Muscle pain and weakness are normal
- D. Juices other than grapefruit juice are okay to use
- E. Statins should be administered in the evening
Correct Answer: A,B,D,E
Rationale: When teaching about statins, the nurse should include information about the possibility of photosensitivity, the need to continue the drug even if feeling better, juices other than grapefruit juice as appropriate, and administration in the evening. MusclePain and weakness should be reported to the client's physician as soon as they occur.
A client who is prescribed niacin comes to the clinic complaining of significant skin flushing and itching. The client states, 'It's really uncomfortable, so much so that I almost stopped taking the drug.' The nurse informs the primary health care provider. Which of the following would the nurse anticipate that the primary health care provider may recommend?
- A. Prednisone
- B. Aspirin
- C. Ibuprofen
- D. Hydrocortisone
Correct Answer: B
Rationale: Aspirin may be recommended before taking niacin preparations to reduce adverse reactions when niacin causes skin reactions that are severe or cause extreme discomfort.