Pharmacology and the Nursing Process Test Bank Free Related

Review Pharmacology and the Nursing Process Test Bank Free related questions and content

A client is scheduled to receive methotrexate (Folex), 0.625 mg/kg P.O. daily, to treat malignant lymphoma. Before administering the drug, the nurse reviews the client’s medication history. Which of the following drugs might interact with methotrexate?

  • A. digoxin (Lanoxin)
  • B. Probenecid (Benemid)
  • C. theophylline (Slo-Phyllin)
  • D. Famotidine (Pepcid)
Correct Answer: B

Rationale: The correct answer is B: Probenecid (Benemid). Probenecid can increase methotrexate levels, leading to potential toxicity. Methotrexate is primarily eliminated by the kidneys, and Probenecid inhibits renal tubular secretion, causing methotrexate levels to rise. Digoxin (A), theophylline (C), and famotidine (D) do not have significant interactions with methotrexate. In summary, Probenecid is the correct answer as it can increase methotrexate levels through renal tubular secretion inhibition, while the other choices do not have a significant interaction with methotrexate.