a definitive diagnosis of sickle cell disease is based on which diagnostic result
Correct Answer: D
Rationale: A definitive diagnosis of sickle cell disease is based on hemoglobin electrophoresis. This test separates the different types of hemoglobin based on their electrical charge, allowing for the detection of abnormal hemoglobin variants such as hemoglobin S, which is characteristic of sickle cell disease. A complete blood count (CBC) can show various abnormalities seen in sickle cell disease, but it is not specific for confirming the diagnosis. Bone marrow aspiration is not routinely used for diagnosing sickle cell disease. Blood chemistry tests may reveal some complications associated with sickle cell disease but do not confirm the condition itself. Hemoglobin electrophoresis is the gold standard for diagnosing sickle cell disease by identifying the specific hemoglobin variant characteristic of the disorder.