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A man is given a drug to reduce thyroid gland size and vascularity before surgical thyroidectomy. Which mechanism is responsible for its use in this setting?
- A. inhibition of the sodium/iodide symporter
- B. inhibition of thyroperoxidase
- C. inhibition of TSH secretion
- D. inhibition of thyroid hormone release
Correct Answer: D
Rationale: Inhibition of thyroid hormone release (e.g., by iodides) reduces gland size and vascularity pre-surgery.
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A nurse is teaching a client who has Graves' disease about her prescribed medications. Which of the following statements by the client indicates an understanding of the use of Propranolol in the treatment of Graves' disease?
- A. Propranolol helps increase blood flow to my thyroid gland.
- B. Propranolol is used to prevent excess glucose in my blood.
- C. Propranolol will decrease my tremors and fast heart beat.
- D. Propranolol promotes a decrease of thyroid hormone in my body
Correct Answer: C
Rationale: Propranolol reduces tremors and tachycardia in Graves' disease by blocking beta-adrenergic effects.
A group of nursing students are reviewing information about drug development in the United States in preparation for an exam. The students demonstrate understanding of this material when they identify testing of which of the following as one of the first steps?
- A. Small group of healthy volunteers
- B. People who have the disease
- C. Live animals
- D. Large numbers of patients
Correct Answer: C
Rationale: Initially, drug testing begins with testing in an artificial environment such as a test tube, and then this testing is followed by testing on live animals. Next, clinical testing occurs with each phase involving a larger number of people. First, a small group of 20 to 100 healthy volunteers are tested; then testing is performed on people who have the disease or condition. Last, the drug is given to large numbers of patients in medical research centers.
A nurse is preparing to administer Amoxicillin 20 mg/kg/day PO to divide equally every 12 hr to a preschooler who weighs 44 lb. The amount available is amoxicillin suspension 250 mg/5 mL. how many mL should the nurse administer per dose? (Round the answer to the nearest whole number. Do not use a trailing zero.)
- A. 4
- B. 7
- C. 1
- D. 10
Correct Answer: A
Rationale: Calculation: 44 lb = 20 kg; 20 mg/kg/day 20 kg = 400 mg/day; 400 mg ÷ 2 doses = 200 mg/dose; 200 mg ÷ (250 mg/5 mL) = 4 mL, matching the answer.
Chlorpromazine can block following receptors EXCEPT:
- A. Dopamine
- B. Beta adrenergic
- C. Alpha adrenergic
- D. Muscarinic
Correct Answer: B
Rationale: Chlorpromazine, a typical antipsychotic, blocks dopamine, alpha-adrenergic, and muscarinic receptors but has minimal effect on beta-adrenergic receptors, which are not its primary target.
Laboratory monitoring for patients on angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers should include:
- A. White blood cell counts with the drug dosage increased for elevations above 10,000 feet
- B. Liver function tests with the drug dosage stopped for alanine aminotransferase values twice that of normal
- C. Serum creatinine levels with the drug dosage reduced for values greater than 2.5 mg/dL
- D. Serum glucose levels with the drug dosage increased for levels greater than 120 mg/dL
Correct Answer: C
Rationale: Elevated creatinine (>2.5 mg/dL) indicates renal impairment, requiring dose adjustment.