A nurse in a provider's office is monitoring serum electrolytes for four older adult clients who take digoxin. Which of the following electrolyte values increases a client's risk for Digoxin toxicity?
- A. Calcium 9.2 mg/dL
- B. Calcium 10.3 mg/dL
- C. Potassium 3.4 mEq/L
- D. Potassium 4.8 mEq/
Correct Answer: C
Rationale: Hypokalemia (3.4 mEq/L, C) increases digoxin toxicity risk by enhancing its effects.
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Which example best demonstrates safe drug administration by the nurse?
- A. Administering an oral medication with the patient sitting upright
- B. Asking children to say their name before administering the medication
- C. Leaving the medications on the bedside stand after verifying patient identification
- D. Returning the unused portion of a medication to a stock supply bottle
Correct Answer: A
Rationale: Sitting the patient upright for oral medications is safe medication practice. Children should never be asked their names as a means of positive identification. Remaining with a patient until the drug is swallowed is safe practice. Returning an unused portion of medication to the stock supply bottle is not safe medication practice.
What is the fraction of unchanged drug reaching the systemic circulation?
- A. Elimination
- B. Bioavailability
- C. Metabolism
- D. Drug displacement
Correct Answer: B
Rationale: Bioavailability is defined as the fraction of unchanged drug that reaches systemic circulation, a key pharmacokinetic parameter.
Tick the second messenger of G-protein-coupled (metabotropic) receptor:
- A. Adenylyl cyclase
- B. Sodium ions
- C. Phospholipase C
- D. cAMP
Correct Answer: D
Rationale: cAMP is a classic second messenger generated by G-protein-coupled receptors via adenylyl cyclase.
Direct renin inhibitors have the following properties. They:
- A. Are primarily generic drugs
- B. Are a renin-angiotensin-aldosterone system (RAAS) medication that is safe during pregnancy
- C. Can be used with an angiotensin-converting enzyme and angiotensin II receptor blocker medications for stronger impact
- D. Shut down' the entire RAAS cycle
Correct Answer: C
Rationale: Direct renin inhibitors (e.g., aliskiren) can be combined with ACEIs or ARBs for enhanced RAAS blockade.
A nurse is providing teaching to a client who has a prescription for Pramlintide for type 1 Diabetes Mellitus. Which of the following should the nurse include in the teaching?(Select one that does not apply.)
- A. Take oral medications 1 hr before injection.
- B. Use upper arms as preferred injection sites.
- C. Mix pramlintide with breakfast dose of insulin.
- D. Inject pramlintide just before a meal.
Correct Answer: D
Rationale: Injecting before meals and discarding after 28 days are key for pramlintide; it's not mixed with insulin.