Nokea
A nurse is collecting data from a client who is taking Gemfibrozil. Which of the following assessment findings should the nurse identify as an adverse reaction to the medication?
- A. Mental status changes
- B. Tremor
- C. Jaundice
- D. Pneumonia
Correct Answer: C
Rationale: Gemfibrozil can cause hepatotoxicity, leading to jaundice .
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Which of the following drugs used for gout decreases net renal tubular reabsorption of uric acid?
- A. Hypoxanthine
- B. Indomethacin
- C. Colchicine
- D. Allopurinol
Correct Answer: C
Rationale: Colchicine reduces inflammation but also decreases uric acid reabsorption indirectly.
Which statement is not correct regarding acarbose:
- A. Is for internal use
- B. Inhibiting alfa glucosidase
- C. Inhibits carbohydrates absorbtion in the gut
- D. Is effective for diabetes mellitus type I
Correct Answer: D
Rationale: Acarbose is primarily effective for type 2 diabetes by delaying carbohydrate absorption, not type 1, which relies on insulin deficiency.
A 35-year-old woman has Graves' disease, a small goiter, and symptoms that are deemed 'mild-to-moderate.' Propylthiouracil is prescribed. Which of the following is the most serious adverse response to this drug, for which close monitoring is required?
- A. Agranulocytosis
- B. Cholestatic jaundice
- C. Gout
- D. Renal tubular necrosis
Correct Answer: A
Rationale: Agranulocytosis is a severe, potentially fatal side effect of propylthiouracil requiring close monitoring due to its impact on white blood cell production.
Which of these beta-blockers is a Class III antiarrhythmic agent?
- A. Metoprolol
- B. Esmolol
- C. Sotalol
- D. Bucindolol
Correct Answer: C
Rationale: Sotalol has both beta-blocking and potassium channel-blocking (Class III) properties, prolonging the action potential.
Which of the following statements is correct?
- A. Most drags are absorbed in ionized form
- B. Basic drags are generally bound to plasma albumin
- C. Microsomal enzymes are located in the mitochondria of hepatic cells
- D. Blood brain barrier is deficient at the chemo receptor trigger-zone
Correct Answer: D
Rationale: The chemoreceptor trigger zone has a deficient blood-brain barrier, allowing drug access; others are incorrect.