Nokea
A nurse is preparing to administer a prescribed medication to a client. The nurse integrates knowledge of which of the following as a possible factor that could influence the drug response?
- A. Age
- B. Polypharmacy
- C. Weight
- D. All the above
Correct Answer: D
Rationale: Drug response can be influenced by the following factors: age, polypharmacy, weight, sex, disease, and genetics.
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A nurse is collecting data from a client who is taking Gemfibrozil. Which of the following assessment findings should the nurse identify as an adverse reaction to the medication?
- A. Mental status changes
- B. Tremor
- C. Jaundice
- D. Pneumonia
Correct Answer: C
Rationale: Gemfibrozil can cause hepatotoxicity, leading to jaundice .
Which of the following combinations of drugs should be used in the treatment of a patient with organophosphate poisoning?
- A. Atropine and epinephrine
- B. Epinephrine and isoproterenol
- C. Norepinephrine and propranolol
- D. Atropine and pralidoxime
Correct Answer: D
Rationale: Atropine blocks muscarinic effects, and pralidoxime regenerates cholinesterase.
Up to 21% of Asians are ultra-rapid 2D6 metabolizers, requiring:
- A. A need to monitor drugs metabolized by 2D6 for toxicity
- B. Increased dosages needed of drugs metabolized by 2D6, such as the selective serotonin reuptake inhibitors
- C. Decreased conversion of codeine to morphine by CYP 2D6
- D. The need for lowered dosages of drugs, such as beta blockers
Correct Answer: B
Rationale: Ultra-rapid 2D6 metabolizers (e.g., in Asians) need higher SSRI doses due to fast metabolism, unlike toxicity , codeine issues , or lower doses .
Human papillomavirus (HPV) vaccine (Gardasil, Cervarix):
- A. Is a live virus vaccine that provides immunity to six strains of HPV virus
- B. Has a common adverse effect of syncope within 15 minutes of giving the vaccine
- C. Should not be given to males younger than age 12 years
- D. May be given to pregnant women
Correct Answer: B
Rationale: HPV vaccine commonly causes syncope post-injection; it's not live , is approved for males 9+ , and is avoided in pregnancy .
Identify poor metabolizers of tamoxifen
- A. Not provided in document
- B. Not provided in document
- C. Not provided in document
- D. Not provided in document
Correct Answer: C
Rationale: This question lacks options, but the answer key (ANS: 3) indicates the third choice. Poor metabolizers of tamoxifen can be identified through CYP2D6 genotyping, as this enzyme converts tamoxifen to its active metabolite.