Nokea
A nurse should monitor a client closely for increased seizure activity when which of the following antineoplastic drugs are used concomitantly with phenytoin (Dilantin)?
- A. Mercaptopurine (Purinethol)
- B. Busulfan (Busulfex)
- C. Thiotepa (Thioplex)
- D. Doxorubicin (Doxil)
- E. Irinotecan (Camptosar)
Correct Answer: B,C,E
Rationale: Plant alkaloids (irinotecan) and alkylating agents (busulfan and thiotepa) can increase risk of seizure when given with phenytoin (Dilantin).
You may also like to solve these questions
A group of nursing students are reviewing antineoplastic drugs. The students demonstrate understanding of the information when they identify which of the following as cell cycle specific?
- A. Alkylating agents
- B. Plant alkaloids
- C. Antimetabolites
- D. Antineoplastic antibiotics
- E. Retinoids
Correct Answer: B,C
Rationale: Plant alkaloids and antimetabolites are considered cell cycle-specific antineoplastic drugs. Alkylating agents and antineoplastic antibiotics are cell cycle-nonspecific agents. Retinoids are miscellaneous agents.
The nurse is providing care to a client with anorexia due to antineoplastic therapy. The nurse identifies a nursing diagnosis of Imbalanced Nutrition: Less Than Body Requirements. Which of the following would be least appropriate for the nurse to include in the client's plan of care?
- A. Offering fatty foods to stimulate the taste buds
- B. Providing small, frequent meals
- C. Avoiding exposure to unpleasant smells
- D. Providing foods that are high in protein
Correct Answer: A
Rationale: Greasy or fatty foods and unpleasant sights, smells, and tastes should be avoided. Small, frequent meals and foods that are high in protein are appropriate.
A nurse should monitor a client closely for signs of worsening atrial fibrillation when which of the following antineoplastic drugs are used concomitantly with digoxin (Lanoxin)?
- A. Mercaptopurine (Purinethol)
- B. Busulfan (Busulfex)
- C. Thiotepa (Thioplex)
- D. Doxorubicin (Doxil)
- E. Irinotecan (Camptosar)
Correct Answer: A,D,E
Rationale: Plant alkaloids (irinotecan), antimetabolites (mercaptopurine), and antineoplastic antibiotics (doxorubicin) can decrease serum digoxin (Lanoxin) levels and result in worsening atrial fibrillation.
A nurse is caring for a client undergoing treatment with plant alkaloids for cancer. The client is also receiving warfarin for a history of atrial fibrillation. The nurse would monitor the client for which of the following as a possible interaction?
- A. Increased risk of seizures
- B. Increased risk of ototoxicity
- C. Increased risk of CNS depression
- D. Increased risk of prolonged bleeding
Correct Answer: D
Rationale: The nurse should monitor the client for the increased risk of prolonged bleeding. Increased risk of seizures occurs when phenytoin interacts with a plant alkaloid. Increased risk of ototoxicity is observed in clients receiving plant alkaloids with loop diuretics. Increased risk of CNS depression is observed in clients who are receiving antidepressants along with plant alkaloids.
A nurse should understand that which of the following adverse effects of antineoplastic drugs are related to the death of rapidly growing cells?
- A. Alopecia
- B. Leukopenia
- C. Stomatitis
- D. Cardiotoxicity
- E. Thrombocytopenia
Correct Answer: A,B,C,E
Rationale: Alopecia, bone marrow suppression (Leukopenia and thrombocytopenia), stomatitis, and diarrhea are adverse effects of antineoplastic drugs and are related to the death of rapidly growing cells.