Nokea
A patient develops hepatotoxicity from chronic acetaminophen use. The primary care NP may recommend:
- A. milk thistle.
- B. chondroitin.
- C. coenzyme Q.
- D. glucosamine.
Correct Answer: A
Rationale: The correct answer is A because milk thistle protects the liver from hepatotoxins like acetaminophen. Choices B, C, and D are incorrect as they lack this hepatoprotective effect.
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Which of the following patients would be at higher risk of experiencing adverse drug reactions (ADRs):
- A. A 32-year-old male
- B. A 22-year-old female
- C. A 3-month-old female
- D. A 48-year-old male
Correct Answer: C
Rationale: Choice C is correct because a 3-month-old female is at higher risk for ADRs due to immature liver and kidney function, reducing drug metabolism and excretion, increasing toxicity potential. Choice A is incorrect as a healthy 32-year-old male typically has mature systems. Choice B is wrong because a 22-year-old female also has developed metabolism. Choice D is incorrect since a 48-year-old male, unless compromised, has lower risk than an infant.
Reasons for restricted distribution of drugs include:
- A. High cost
- B. Serious safety concerns
- C. Limited supply
- D. All of the above
Correct Answer: B
Rationale: Choice B is correct because restricted distribution (e.g., REMS) is primarily for drugs with serious safety risks (e.g., thalidomide), not cost or supply alone. Choice A is incorrect as cost doesn't mandate restriction—insurance handles that. Choice C is wrong because limited supply isn't a REMS trigger. Choice D is incorrect since only B is the core reason.
Drugs that use CYP 3A4 isoenzymes for metabolism may:
- A. Induce the metabolism of another drug
- B. Inhibit the metabolism of another drug
- C. Both 1 and 2
- D. Neither 1 nor 2
Correct Answer: C
Rationale: Choice C is correct because CYP 3A4 drugs can induce (speed up) or inhibit (slow down) metabolism of other drugs sharing this pathway, affecting their levels and efficacy. Choice A is incorrect as it's only half the story—induction happens, but inhibition does too. Choice B is wrong because it misses induction potential. Choice D is incorrect since both effects are well-documented with CYP 3A4.
A client with a diagnosis of heart failure is prescribed spironolactone (Aldactone). Which laboratory value should the nurse monitor closely?
- A. Serum calcium
- B. Serum potassium
- C. Serum sodium
- D. Serum glucose
Correct Answer: B
Rationale: The correct answer is B: Serum potassium. Spironolactone is a potassium-sparing diuretic, which can lead to hyperkalemia. Monitoring serum potassium levels is crucial to prevent potential complications related to high potassium levels, such as cardiac arrhythmias. Therefore, close monitoring of serum potassium is essential for clients taking spironolactone. Choices A, C, and D are incorrect because spironolactone does not directly impact serum calcium, sodium, or glucose levels significantly. While these values may be monitored for other reasons in a client with heart failure, they are not the primary focus of monitoring when spironolactone is prescribed.
An 81-year-old male client has emphysema. He lives at home with his cat and manages self-care with no difficulty. When making a home visit, the nurse notices that this client's tongue is somewhat cracked, and his eyeballs appear sunken into his head. Which nursing intervention is indicated?
- A. Help the client determine ways to increase his fluid intake.
- B. Obtain an appointment for the client to have an eye examination.
- C. Instruct the client to use oxygen at night and increase humidification.
- D. Schedule the client for tests to determine his sensitivity to cat hair.
Correct Answer: A
Rationale: The client's cracked tongue and sunken eyes indicate dehydration. Therefore, the priority nursing intervention is to help the client determine ways to increase his fluid intake. Dehydration can exacerbate the client's emphysema symptoms and lead to further complications. Monitoring and addressing the client's fluid intake is crucial for maintaining his health and well-being. Options B, C, and D are not the immediate priorities in this situation. While an eye examination, oxygen use, and sensitivity tests are relevant aspects of care, addressing dehydration through increased fluid intake takes precedence in this scenario.