Nokea
A patient ill with amebiasis was prescribed a certain drug. The use of alcohol together with this drug is contraindicated because the drug inhibits metabolism of ethyl alcohol. What drug is it?
- A. Metronidazole
- B. Reserpine
- C. Clonidine
- D. Diazepam
Correct Answer: A
Rationale: Rationale:
1. Metronidazole is known to inhibit aldehyde dehydrogenase, an enzyme involved in alcohol metabolism.
2. Inhibition of this enzyme leads to accumulation of acetaldehyde, causing unpleasant symptoms when alcohol is consumed.
3. This reaction is known as the disulfiram-like reaction.
4. Reserpine, Clonidine, and Diazepam do not have this specific mechanism of action.
Summary:
- Option A (Metronidazole) is correct due to its inhibition of alcohol metabolism.
- Options B, C, and D are incorrect as they do not exhibit this interaction with alcohol metabolism.
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A Gram-negative, comma-shaped bacterium was isolated from a patient with cholera. What is the most likely causative agent?
- A. Vibrio cholerae
- B. Shigella dysenteriae
- C. Salmonella typhi
- D. Campylobacter jejuni
Correct Answer: A
Rationale: The correct answer is A: Vibrio cholerae. This is because Vibrio cholerae is a Gram-negative, comma-shaped bacterium known to cause cholera. The characteristic shape and the association with cholera make it the most likely causative agent in this case.
Explanation for incorrect choices:
B: Shigella dysenteriae - Shigella dysenteriae is a Gram-negative bacterium that causes bacillary dysentery, not cholera.
C: Salmonella typhi - Salmonella typhi is a Gram-negative bacterium that causes typhoid fever, not cholera.
D: Campylobacter jejuni - Campylobacter jejuni is a Gram-negative bacterium that commonly causes foodborne gastroenteritis, not cholera.
A 43-year-old cattle farm worker is brought to the surgeon with fever, malaise, and inflamed lesions on his hands and arms. He reports that about 2 weeks before his presentation at the hospital he noticed small, painless, pruritic papules that quickly enlarged and developed a central vesicle. The vesicles developed into erosion and left painless necrotic ulcers with black, depressed eschar. Gram's staining of the ulcer reveals gram-positive spore-forming bacilli. Which of the following diseases is the most likely cause of these findings?
- A. Anthrax
- B. Chickenpox
- C. Syphilis
- D. Tularemia
Correct Answer: A
Rationale: The correct answer is A: Anthrax. The clinical presentation of painless necrotic ulcers with black eschar, along with the gram-positive spore-forming bacilli seen on Gram's staining, is classic for cutaneous anthrax. Anthrax is caused by Bacillus anthracis, which produces spores and can lead to skin lesions in individuals working with animals or animal products. Choice B, Chickenpox, typically presents with vesicular rash all over the body. Choice C, Syphilis, is caused by Treponema pallidum and does not present with the characteristic eschar seen in the patient. Choice D, Tularemia, caused by Francisella tularensis, presents with ulceroglandular lesions but lacks the black eschar characteristic of anthrax.
Which of the following bacteria are known for causing urinary tract infections?
- A. Escherichia coli
- B. Pseudomonas aeruginosa
- C. Staphylococcus aureus
- D. All of the above
Correct Answer: D
Rationale: The correct answer is D (All of the above) because all three bacteria (Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus) are known to cause urinary tract infections. E. coli is the most common causative agent of UTIs due to its ability to colonize the urethra. P. aeruginosa can cause UTIs in hospitalized patients with catheters. S. aureus is less common but can lead to UTIs, especially in individuals with underlying health conditions. Therefore, all three bacteria are potential pathogens for UTIs. Choices A, B, and C are incorrect because each of these bacteria can individually cause UTIs, making the correct answer D.
Clinical symptom, typical for erythema infectiosum is:
- A. Swelling of salivary glands
- B. Diarrhea
- C. Hepatitis
- D. Exanthematous rash
Correct Answer: D
Rationale: The correct answer is D: Exanthematous rash. Erythema infectiosum, also known as fifth disease, is characterized by a distinctive rash on the cheeks that looks like a "slapped cheek." This rash then spreads to the rest of the body, resulting in a lace-like rash (exanthem). Swelling of salivary glands (choice A) is not a typical symptom of erythema infectiosum. Diarrhea (choice B) and hepatitis (choice C) are also not associated with this condition. Therefore, the most characteristic clinical symptom of erythema infectiosum is the exanthematous rash.
OSHA was established in
- A. 1921
- B. 1971
- C. 1980
- D. 1985
Correct Answer: B
Rationale: The correct answer is B: 1971. OSHA, the Occupational Safety and Health Administration, was established in 1971 under the Occupational Safety and Health Act signed by President Richard Nixon. This act aimed to ensure safe and healthy working conditions for employees by setting and enforcing standards. Choices A, C, and D are incorrect as OSHA was not established in those years. Option A (1921) is too early, option C (1980) is after OSHA was already established, and option D (1985) is also too late. Therefore, the correct answer is B, 1971, as it aligns with the historical establishment of OSHA.