ATI Pathophysiology Test Bank Related

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A patient is receiving intravenous amphotericin. Which of the following assessments warrants the discontinuation of the antifungal agent?

  • A. Sodium level of 138 mEq/L
  • B. Hematocrit of 39%
  • C. Blood urea nitrogen of 60 mg/dL
  • D. AST level of 10 Unit/L
Correct Answer: C

Rationale: Intravenous amphotericin can cause nephrotoxicity, leading to increased blood urea nitrogen levels. Elevated blood urea nitrogen (BUN) indicates impaired renal function, which is a known adverse effect of amphotericin. Therefore, a BUN level of 60 mg/dL warrants the discontinuation of the antifungal agent. The other options, such as a sodium level of 138 mEq/L, hematocrit of 39%, and AST level of 10 Unit/L, are within normal ranges and not indicative of the need to discontinue amphotericin therapy.