An agonist is substance that:
- A. Interacts with the receptor without producing any effect
- B. Interacts with the receptor and initiates changes in cell function, producing various effects
- C. Increases concentration of another substance to produce effect
- D. Interacts with plasma proteins and doesn't produce any effect
Correct Answer: B
Rationale: An agonist binds receptors and activates them, producing a biological effect.
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Patients receiving heparin therapy require monitoring of:
- A. Platelets every 2 to 3 days for thrombocytopenia that may occur on day 4 of therapy
- B. Electrolytes for elevated potassium levels in the first 24 hours of therapy
- C. INR throughout therapy to stay within the range of 2.0
- D. Blood pressure for hypertension that may occur in the first 2 days of treatment
Correct Answer: A
Rationale: Heparin can cause thrombocytopenia (HIT) around day 4, requiring platelet checks; INR is for warfarin, not heparin.
Medication orders are written with very specific criteria and coincide with the 7 rights of medication administration. What critical piece of information is missing from the following medication order? Amoxicillin 250 mg every 8 hours.
- A. Dose
- B. Route
- C. Frequency of administration
- D. Trade name of the drug
Correct Answer: B
Rationale: The route (e.g., oral, IV) is missing, essential for safe administration per the 7 rights.
Carvedilol is heavily metabolized by CYP2D6 and 2C9, resulting in drug interactions with which of the following drug classes?
- A. Histamine 2 blockers
- B. Quinolones
- C. Serotonin re-uptake inhibitors
- D. All of the above
Correct Answer: C
Rationale: SSRIs inhibit CYP2D6, increasing carvedilol levels and effects.
A good history of herb and supplement use is critical before prescribing because approximately % of patients in the United States are using herbal products.
- A. 10
- B. 5
- C. 38
- D. 70
Correct Answer: C
Rationale: Approximately 38% of U.S. patients use herbal products, necessitating a thorough history.
The U.S. Drug Enforcement Administration:
- A. Registers manufacturers and prescribers of controlled substances
- B. Regulates NP prescribing at the state level
- C. Sanctions providers who prescribe drugs off-label
- D. Provides prescribers with a number they can use for insurance billing
Correct Answer: A
Rationale: The DEA registers those handling controlled substances , not state NP rules , off-label sanctions , or insurance numbers .