An inflammatory disease that can develop as a complication following a group A streptococcal infection is:
- A. endocarditis
- B. rheumatic fever
- C. nephritis
- D. cytomegalovirus
Correct Answer: B
Rationale: The correct answer is B: rheumatic fever. Rheumatic fever is an inflammatory disease that can occur as a complication following a group A streptococcal infection. This is known as a post-streptococcal complication. It typically affects the heart, joints, skin, and brain. Endocarditis (choice A) is also a complication of streptococcal infections, but it is an infection of the heart valves, not an inflammatory disease like rheumatic fever. Nephritis (choice C) is inflammation of the kidneys and is not directly related to streptococcal infections. Cytomegalovirus (choice D) is a different viral infection and is not associated with streptococcal infections.
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The First-line tuberculosis drugs include:
- A. Isoniazid and rifampicin
- B. Penicillin and erythromycin
- C. Trimethoprim and third generation cephalosporins
- D. All the listed above can be used depending on their resistance profile
Correct Answer: A
Rationale: The correct answer is A: Isoniazid and rifampicin. These drugs are considered first-line treatment for tuberculosis due to their high efficacy and low toxicity. Isoniazid targets the cell wall of the tuberculosis bacteria, while rifampicin inhibits RNA synthesis. They are recommended by WHO as the first choice for treating tuberculosis.
Choice B (Penicillin and erythromycin) is incorrect because these antibiotics are not effective against tuberculosis bacteria.
Choice C (Trimethoprim and third generation cephalosporins) is incorrect because they are not considered first-line drugs for tuberculosis treatment.
Choice D (All the listed above can be used depending on their resistance profile) is incorrect because only isoniazid and rifampicin are universally recognized as first-line drugs for tuberculosis regardless of resistance profile.
Which of the following is not a bacterial antibiotic resistance mechanism
- A. Reduced permeability
- B. Cell-wall regrowth
- C. Over-expression of target
- D. c) Efflux pump
Correct Answer: B
Rationale: The correct answer is B: Cell-wall regrowth. This is not a bacterial antibiotic resistance mechanism because antibiotics target specific components in bacteria, such as cell wall synthesis, making regrowth impossible in the presence of antibiotics. Reduced permeability (A) decreases antibiotic entry, Over-expression of target (C) reduces antibiotic effectiveness, and Efflux pump (D) actively removes antibiotics from the cell, all contributing to antibiotic resistance. In summary, cell-wall regrowth is not a mechanism of antibiotic resistance, unlike the other choices that actively promote bacterial survival against antibiotics.
Which bacteria are known for producing toxins that can lead to foodborne illnesses?
- A. Clostridium botulinum
- B. Salmonella enterica
- C. Escherichia coli
- D. All of the above
Correct Answer: D
Rationale: The correct answer is D because all three bacteria (Clostridium botulinum, Salmonella enterica, Escherich:ia coli) are known to produce toxins causing foodborne illnesses. Clostridium botulinum produces botulinum toxin, causing botulism. Salmonella enterica produces toxins leading to salmonellosis. Escherichia coli can produce toxins like Shiga toxin causing food poisoning. Choices A, B, and C are incorrect because each bacterium is individually known to produce toxins causing foodborne illnesses, thus the correct answer is D.
The causative agent of the disease gas gangrene Clostridium perfringens is:
- A. Gram-negative rod-shaped bacteria, fixed with capsule
- B. Gram-negative rod-shaped bacterium, motile, peritrichous without capsule
- C. Gram-positive rod-shaped bacterium, motile, peritrichous without capsule
- D. Gram-positive rod-shaped bacterium non-motile, with capsule
Correct Answer: C
Rationale: The correct answer is C because Clostridium perfringens is a Gram-positive rod-shaped bacterium, which matches the description provided. It is motile and peritrichous (having flagella all over the surface) without a capsule. This bacterium is known to cause gas gangrene due to its ability to produce toxins that destroy tissue.
Choice A is incorrect because Clostridium perfringens is Gram-positive, not Gram-negative, and it does not have a capsule. Choice B is incorrect because Clostridium perfringens is not motile and does not have flagella all over its surface. Choice D is incorrect because Clostridium perfringens is Gram-positive, not Gram-negative, and it is motile without a capsule.
Which of the following is characteristic of obligate anaerobes?
- A. They require oxygen to survive
- B. They can survive in the presence or absence of oxygen
- C. They cannot tolerate oxygen
- D. They prefer low levels of oxygen
Correct Answer: C
Rationale: The correct answer is C: Obligate anaerobes cannot tolerate oxygen. They lack the enzymes needed to detoxify reactive oxygen species generated in the presence of oxygen. This makes them unable to survive in oxygen-rich environments. Choice A is incorrect because obligate anaerobes do not require oxygen to survive. Choice B is incorrect because obligate anaerobes specifically require the absence of oxygen. Choice D is incorrect because obligate anaerobes cannot even tolerate low levels of oxygen.