Nokea
An Investigational New Drug is filed with the U.S. Food and Drug Administration:
- A. When the manufacturer has completed phase III trials
- B. When a new drug is discovered
- C. Prior to animal testing of any new drug entity
- D. Prior to human testing of any new drug entity
Correct Answer: D
Rationale: An IND is filed before human testing , after preclinical (animal) studies, to ensure safety before clinical trials begin.
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Rabi is being prescribed phenytoin for seizures. Monitoring includes assessing:
- A. For phenytoin hypersensitivity syndrome 3 to 8 weeks after starting treatment
- B. For pedal edema throughout therapy
- C. Heart rate at each visit and consider altering therapy if heart rate is less than 60 bpm
- D. For vision changes, such as red-green blindness, at least annually
Correct Answer: A
Rationale: Phenytoin hypersensitivity syndrome can occur 3-8 weeks post-initiation.
A 32-year-old female is dehydrated after running a marathon in hot and humid weather. She requires an IV fluid to increase the blood volume and rehydrate the cells. Which one of the following IV fluids would be appropriate for her condition?
- A. Hypertonic crystalloid solution
- B. Isotonic crystalloid solution
- C. Packed red blood cells
- D. Hypotonic crystalloid solution
Correct Answer: B
Rationale: Isotonic solutions (e.g., normal saline) restore volume and hydration without shifting fluids excessively.
Chlorpropamide metabolism is enhanced by
- A. Ethyl alcohol
- B. Diazepam
- C. Lorazepam
- D. Chloridazepoxide
Correct Answer: A
Rationale: Ethyl alcohol induces hepatic enzymes, enhancing the metabolism of chlorpropamide, a sulfonylurea antidiabetic drug.
The client with squamous cell carcinoma of the larynx is receiving bleomycin intravenously. The nurse caring for the client anticipates that which diagnostic study will be prescribed?
- A. Echocardiography
- B. Electrocardiography
- C. Cervical radiography
- D. Pulmonary function studies
Correct Answer: D
Rationale: Bleomycin is an antineoplastic medication (Chemotherapeutic Agents) that can cause interstitial pneumonitis, which can progress to pulmonary fibrosis. Pulmonary function studies along with hematological, hepatic, and renal function tests need to be monitored. The nurse needs to monitor lung sounds for dyspnea and crackles, which indicate pulmonary toxicity. The medication needs to be discontinued immediately if pulmonary toxicity occurs. Options 1, 2, and 3 are unrelated to the specific use of this medication.
The nurse is caring for a client who has a nasogastric tube in place. The client is to receive an oral medication through the tube. Which action by the nurse would be most appropriate? (Select one that does not apply.)
- A. Not diluting liquids prior to administration
- B. Checking the tube for placement
- C. Dissolving crushed tablets in water prior to administration
- D. Flushing the tube with water after drugs are administered
Correct Answer: A
Rationale: Before administration of an oral drug through an NG tube or gastrostomy tube, the nurse should check the tube for placement, dilute and flush liquid drugs through the tube, crush tablets and dissolve them in water before administering them through the tube, and flush the tube with water after the drugs are placed in the tube to clear the tubing completely.