Nokea
An overdose of amitriptyline may precipitate all the following adverse effects EXCEPT:
- A. Cardiac arrhythmias
- B. Hypotension
- C. Sedation
- D. Jaundice
Correct Answer: D
Rationale: Amitriptyline overdose does not typically cause jaundice; it causes anticholinergic and cardiac effects.
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Food can alter the pH of the stomach, leading to:
- A. Enhanced drug metabolism
- B. Altered vitamin K absorption
- C. Increased vitamin D absorption
- D. Altered drug bioavailability
Correct Answer: D
Rationale: Changes in stomach pH due to food can affect drug dissolution and absorption, altering bioavailability.
All the following induce hepatic enzymes except
- A. Rifampicin
- B. Phenytoin
- C. Barbiturates
- D. Tolbutamide
Correct Answer: D
Rationale: Tolbutamide does not significantly induce enzymes; others do.
Which of the following can be used with parenteral route for the treatment of diabetes mellitus
- A. Insulin preparations
- B. Sulfonilureas
- C. Biguanides
- D. Acarbose
Correct Answer: A
Rationale: Insulin is the only diabetes medication administered parenterally (e.g., subcutaneous or IV).
You need to administer 200 mL of a drug over 30 minutes using microdrip tubing (60 gtt/mL). What is the flow rate in drops per minute?
- A. 60 gtt/min
- B. 120 gtt/min
- C. 400 gtt/min
- D. 240 gtt/min
Correct Answer: C
Rationale: Flow rate = (200 mL 60 gtt/mL) ÷ 30 = 12,000 ÷ 30 = 400 gtt/min, matching option C.
Which drug reference contains monographs about virtually every single-entity drug available in the United States and describes therapeutic uses of drugs, including approved and unapproved uses?
- A. Martindale: The Complete Drug Reference
- B. AHFS Drug Information
- C. Drug Reference
- D. Drug Facts and Comparisons
Correct Answer: B
Rationale: AHFS Drug Information contains monographs about virtually every single-entity drug available in the United States and describes therapeutic uses of drugs, including approved and unapproved uses.