At the skeletal muscle sarcomere, Ca2+ ions do each of the following, except:
- A. Bind to troponin to help uncover tropomyosin
- B. Help expose active sites on actin strands
- C. Is stored in the sarcoplasmic reticulum at terminal cisternae
- D. Helps break the ATP into ADP + inorganic phosphate readying the myosin head to bind another active site
Correct Answer: d
Rationale: Rationale for Correct Answer (D):
1. Ca2+ ions do not directly break down ATP into ADP + inorganic phosphate at the sarcomere.
2. This breakdown occurs through the enzymatic action of myosin ATPase.
3. Ca2+ ions primarily bind to troponin to initiate muscle contraction by moving tropomyosin.
4. Ca2+ ions help expose active sites on actin, facilitating cross-bridge formation.
Summary of Incorrect Choices:
A. Correct - Ca2+ binds to troponin to move tropomyosin, not to uncover it.
B. Correct - Ca2+ aids in exposing active sites on actin, not troponin.
C. Correct - Ca2+ is stored in the sarcoplasmic reticulum, but it is released into the cytoplasm to trigger muscle contraction, not stored in the terminal cisternae.
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Correct Answer: D
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- A. parathyroid hormone
- B. calcitonin
- C. oxytocin
- D. glucagon
Correct Answer: B
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- A. Nodules.
- B. Islets of Langerhans.
- C. Pancreatic medulla.
- D. Pancreatic cortex.
Correct Answer: B
Rationale: The correct answer is B: Islets of Langerhans. These are clusters of cells in the pancreas responsible for producing hormones like insulin and glucagon. The islets regulate blood sugar levels. Nodules (A) are not specific to the pancreas. Pancreatic medulla (C) and pancreatic cortex (D) do not refer to the specific clusters of cells in the pancreas that produce hormones.
Why are the hormones cortisol, glucagon, epinephrine, and growth hormone referred to as counter regulatory hormones?
- A. Decrease glucose production
- B. Stimulate glucose output by the liver
- C. Increase glucose transport into the cells
- D. Independently regulate glucose level in the blood
Correct Answer: B
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Peptide hormones _______________.
- A. are hydrophilic
- B. cannot enter the target cell
- C. bind to a receptor on the cell surface
- D. all of these
Correct Answer: D
Rationale: The correct answer is D because peptide hormones are hydrophilic molecules that cannot pass through the cell membrane, so they bind to receptors on the cell surface to initiate signaling pathways within the cell. Therefore, they are unable to enter the target cell like lipid-soluble hormones do. By binding to specific receptors on the cell surface, peptide hormones trigger a series of events that ultimately lead to a cellular response. Therefore, all of the given statements are true, making D the correct choice.