Nokea
Azathioprine has significant adverse drug effects, including:
- A. Hypertension
- B. Hirsutism
- C. Risk of cancer
- D. Gingival hyperplasia
Correct Answer: C
Rationale: Azathioprine increases cancer risk (e.g., lymphoma) via immunosuppression; other effects (A, B, D) are less prominent.
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____ is / are prescribed to prevent swimmer's ear.
- A. Ciprofloxacin otic drops (Ciloxan)
- B. Isopropyl ear drops (EarSol)
- C. Colistin (Coly-Mycin S Otic)
- D. Gentamicin otic drops
Correct Answer: B
Rationale: Isopropyl alcohol dries the ear canal, preventing swimmer's ear; antibiotics treat, not prevent.
The treatment of hyperlipidemia with gemfibrozil plus lovastatin is associated with a high risk of:
- A. Constipation
- B. Myopathy
- C. Hepatitis
- D. Thrombocytopenia
Correct Answer: B
Rationale: Combining gemfibrozil and statins increases the risk of myopathy due to elevated statin levels.
Six-year-old Lucy has recently been started on ethosuximide (Zarontin) for seizures. She should be monitored for:
- A. Increased seizure activity, as this drug may auto-induce seizures
- B. Altered renal function, including renal failure
- C. Blood dyscrasias, which are uncommon but possible
- D. Central nervous system excitement, leading to insomnia
Correct Answer: C
Rationale: Ethosuximide can rarely cause blood dyscrasias, requiring monitoring.
The patient is taking a drug that affects the body by increasing cellular activity. Where does this drug work on the cell?
- A. Receptor sites
- B. Cell membrane
- C. Golgi body
- D. Endoplasmic reticulum
Correct Answer: A
Rationale: Many drugs are thought to act at specific areas on cell membranes called receptor sites. After the receptor site is activated, this in turn activates the enzyme systems to produce certain effects, such as increased or decreased cellular activity, changes in cell membrane permeability, or alterations in cellular metabolism. Receptor sites are generally located on the outside of cells and allow the drug to bypass the cell membrane. The Golgi body and endoplasmic reticulum are not involved in this process.
Which of the following anti inflammatory drugs is ineffective in gout?
- A. Piroxicam
- B. Tolmetin
- C. Aspirin
- D. Celecoxib
Correct Answer: C
Rationale: Aspirin increases uric acid levels, worsening gout.