Nokea
Candesartan and irbesartan are angiotensin receptor blockers that are used to treat hypertension. The therapeutic dose range for candesartan is 4 to 32 mg, as compared to 75 to 300 mg for irbesartan. which of the following regarding this statement is correct?
- A. Candesartan is more potent than is irbesartan
- B. Candesartan and irbesartan have different efficacy
- C. Candesartan is a non competitive antagonist for irbesartan
- D. Irbesartan is a competitive antagonist for candesartan
Correct Answer: A
Rationale: Lower dose range for candesartan indicates higher potency (lower EC50) compared to irbesartan.
You may also like to solve these questions
The nurse is assessing a diabetic patient who has presented at the clinic reporting several hypoglycemic episodes during the past 3 weeks. The nurse questions the patient about the use of herbal or alternative therapies, suspecting what herbal remedy could cause the hypoglycemic episodes?
- A. St. John's wort
- B. Kava
- C. Fish oil
- D. Ginseng
Correct Answer: D
Rationale: Ginseng is known to decrease blood sugar levels. If the patient used this in combination with his or her oral antidiabetic agent, diet, and exercise, his or her blood sugar could drop below therapeutic levels. St. John's wort interacts with many drugs, but not with antidiabetic agents. Kava is associated with liver toxicity. Fish oil has been associated with decreased coronary artery disease.
The mean weight of 500 college students is 70 kg and the standard deviation is 3 kg. Assuming that the weight is normally distributed, determine how many students weigh less than 64 kg.
- A. 5
- B. 11
- C. 15
- D. 20
Correct Answer: B
Rationale: Z-score: (64-70)/3 = -2. P(Z < -2) = 1 - P(Z ≤ 2). Using standard tables, P(Z ≤ 2) ≈ 0.9772, so P(Z < -2) = 1 - 0.9772 = 0.0228 (document says 0.02128, likely a typo). Then, 0.0228 * 500 ≈ 11, matching the document.
Please select a correct statement:
- A. Steroids excreted in maximal amount in evening and night time - between 20-24 h
- B. Steroids maximal excretion is in morning time - between -4-8 h
- C. Steroids maximal secretion is in daytime- between -12-16 h
- D. Steroids decrease sensitivity of vessels and bronchus towards catecholamines
Correct Answer: B
Rationale: Steroids peak in the morning (4-8 AM) due to circadian rhythm of cortisol secretion.
45 year old female has a diabetes mellitus. Endocrinologist prescribes treatment, which has a side effect as hypoglycemia and weight gain. Which of the following drug is prescribed?
- A. Canagliflozin
- B. Exenatide
- C. Gliburide
- D. Pramlintide
Correct Answer: C
Rationale: Gliburide, a sulfonylurea, commonly causes hypoglycemia and weight gain due to increased insulin release.
All of the following adverse effects commonly occur in glucocorticoid therapy except:
- A. Osteoporosis
- B. Increased risk of infection
- C. Hypotension
- D. Emotional disturbances
Correct Answer: C
Rationale: Glucocorticoids cause hypertension, not hypotension, due to mineralocorticoid effects and fluid retention.